Hearing results with combination steroid therapy for sudden sensorineural hearing loss.

Edgar A García-Rodríguez, Francisco J Mancilla-Mejía, Silvia L Dirzo-Cuevas, Abraham Hernández-Mundo, Luis M Méndez-Saucedo
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Abstract

Background: Sudden Sensorineural Hearing Loss was described by Mc. Cabe in 1979 and, since then, many authors have tried to define, explain and correctly treat this disease. The National Institute on Deafness and Other Communication Disorders defines it as sudden sensorineural hearing loss of at least 30 dB in three contiguous audiometric frequencies in a period of 72 hours. Among the therapeutic strategies, corticosteroids have been shown to have the greatest benefit due to their anti-inflammatory and anti-cellular stress effects.

Objective: To determine the hearing results with combined steroid therapy in patients with sudden sensorineural hearing loss (SSHL), according to the Siegel recovery criteria scale.

Method: Study carried out in the otorhinolaryngology and head and neck surgery service of the Centro Médico Naval, Ciudad de México, where 150 patients diagnosed with SSHL and who received combined therapy with intratympanic dexamethasone and systemic prednisone were included.

Results: Therapeutic effectiveness was demonstrated by correlating therapeutic success in 82% of cases and therapeutic failure in 18% of cases, by correlating it with the Siegel recovery criteria scale. When evaluating the general average of the pure tone average levels at the beginning and 6 weeks after treatment, a statistically significant difference was obtained (p = 0.001). The average of the speech audiometry at the beginning and 6 weeks later had a statistically significant difference (p = 0.001).

Conclusions: Initial combined steroid treatment for SSHL has been shown to have beneficial results according to Siegel recovery criteria scale.

联合类固醇疗法治疗突发性感音神经性听力损失的听力效果。
背景介绍突发性感音神经性听力损失由 Mc.Cabe 于 1979 年描述了突发性感音神经性听力损失,自此以后,许多学者都试图定义、解释和正确治疗这种疾病。美国国家耳聋和其他交流障碍研究所将其定义为 72 小时内三个连续听力频率至少下降 30 分贝的突发性感音神经性听力损失。在各种治疗策略中,皮质类固醇因其抗炎和抗细胞压力作用而被证明具有最大疗效:根据西格尔康复标准量表,确定联合类固醇疗法对突发性感音神经性听力损失(SSHL)患者的听力效果:在墨西哥城海军医疗中心耳鼻咽喉头颈外科进行的研究,纳入了 150 名被诊断为突发性感音神经性听力损失(SSHL)并接受鼓室内地塞米松和全身性泼尼松联合治疗的患者:结果:82%的病例治疗成功,18%的病例治疗失败,治疗效果与西格尔康复标准量表相关联。在评估治疗初期和治疗 6 周后纯音平均水平的总体平均值时,发现两者之间存在显著的统计学差异(P = 0.001)。开始时和治疗 6 周后的言语测听平均值在统计学上有显著差异(p = 0.001):结论:根据西格尔康复标准量表,SSHL的初始联合类固醇治疗效果良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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