Royan Institute First Attempts: Autotransplantation of Vitrified Human Ovarian Tissue in Cancer Patients.

IF 1.7 4区生物学 Q4 CELL BIOLOGY

Cell Journal Pub Date : 2023-11-01 DOI:10.22074/cellj.2023.2000360.1289

Naeimeh Sadat Abtahi, Bita Ebrahimi, Firouzeh Ghaffari, Rohollah Fathi, Mojtaba Rezazadeh Valojerdi, Abolfazl Mehdizadehkashi, Sepideh Khodaverdi, Azar Yahyaei, Maziar Faridi

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引用次数: 0

Abstract

Today, timely diagnosis and therapeutic progress open a road of hope for survival in cancerous patients. Increased knowledge about the various cytotoxic treatment's impacts on ovarian function and fertility has resulted in a surge in the number of patients seeking to preserve their fertility before starting the anti-cancer treatment process. In this regard, embryo cryopreservation can be recommended for fertility preservation when the woman is married and has adequate time for ovarian stimulation. If patients are prepubertal girls or not married women, oocytes or ovarian tissue can be frozen instead to be used in the future. In this regard, the first attempts for ovarian tissue transplantations were conducted in 2016 and in 2019 for two cancerous patients whose ovarian tissue was cryopreserved in the Royan Human Ovarian Tissue Bank (Tehran, Iran). Unfortunately, the transplantations did not result in a live birth.

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罗扬研究所首次尝试：为癌症患者进行玻璃化人类卵巢组织的自体移植。

如今，及时的诊断和治疗进展为癌症患者的生存开辟了一条希望之路。随着人们对各种细胞毒性治疗对卵巢功能和生育能力影响的认识不断加深，寻求在开始抗癌治疗前保留生育能力的患者人数激增。在这方面，当妇女已婚并有足够的时间进行卵巢刺激时，可建议进行胚胎冷冻以保存生育能力。如果患者是青春期前的少女或未婚女性，则可以冷冻卵母细胞或卵巢组织，以备将来使用。在这方面，2016 年和 2019 年对两名癌症患者进行了卵巢组织移植的首次尝试，这两名患者的卵巢组织被冷冻保存在 Royan 人类卵巢组织库（伊朗德黑兰）中。遗憾的是，移植手术并没有带来活产。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Journal CELL BIOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

审稿时长

12 months

期刊介绍： The “Cell Journal (Yakhteh)“, formerly published as “Yakhteh Medical Journal”, is a quarterly English publication of Royan Institute. This journal focuses on topics relevant to cellular and molecular scientific areas, besides other related fields. The Cell J has been certified by Ministry of Culture and Islamic Guidance in 1999 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2000 which is an open access journal.