Body fluid volume calculated using the uric acid kinetic model relates to the vascular event.

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Journal of Artificial Organs Pub Date : 2024-09-01 Epub Date: 2023-12-11 DOI:10.1007/s10047-023-01421-z
Shigeru Nakai, Takahito Ito, Kazuhiko Shibata, Kiyoshi Ozawa, Teppei Matsuoka, Kanenori Maeda, Yasushi Ohashi, Takayuki Hamano, Norio Hanafusa, Takahiro Shinzato, Susumu Ookawara, Ikuto Masakane
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引用次数: 0

Abstract

Purpose: We developed a method to measure the extracellular and intracellular fluid volumes using the kinetics of uric acid in the bodies of Japanese patients undergoing dialysis. In this research, we aimed to assess the prognosis of vascular events using this uric acid kinetic model method.

Methods: We conducted a retrospective cohort study of 1,298 patients who were undergoing hemodialysis or predilution online hemodiafiltration at the end of December 2019 at 13 institutions in Japan. Information on vascular events was acquired in 2020. Vascular event prognosis was defined as the new incidence of one or more of the following four types of vascular events: myocardial infarction, cerebral infarction, cerebral hemorrhage, or limb amputation. We measured the extracellular fluid volume and intracellular fluid volume after dialysis using the uric acid kinetic model method and determined the association between ECV, ICV, and vascular event risk.

Results: A high extracellular volume was substantially linked to an increased risk of vascular events. In addition, while a crude analysis revealed that a high intracellular volume was associated with a low risk of vascular events, this was not statistically significant after multifactorial adjustment. This result was partly affected by the low measurement accuracy of the serum urea nitrogen level used for the intracellular volume calculation.

Conclusions: Extracellular volume calculated using the uric acid kinetic model method is a prognostic factor for vascular events in patients undergoing hemodialysis.

Abstract Image

使用尿酸动力学模型计算的体液容量与血管事件有关。
目的:我们开发了一种利用日本透析患者体内尿酸动力学测量细胞外液和细胞内液容量的方法。在这项研究中,我们旨在利用这种尿酸动力学模型方法评估血管事件的预后:我们对2019年12月底在日本13家机构接受血液透析或预稀释在线血液透析的1298名患者进行了回顾性队列研究。有关血管事件的信息于 2020 年获得。血管事件预后被定义为以下四种血管事件中一种或多种的新发生率:心肌梗死、脑梗死、脑出血或肢体截肢。我们使用尿酸动力学模型法测量了透析后的细胞外液容量和细胞内液容量,并确定了ECV、ICV与血管事件风险之间的关联:结果:细胞外液容量高与血管事件风险增加有很大关系。此外,虽然粗略分析显示细胞内容量大与血管事件风险低有关,但经多因素调整后,这一结果在统计学上并不显著。这一结果部分受到了用于计算细胞内容量的血清尿素氮水平测量准确性较低的影响:结论:使用尿酸动力学模型方法计算的细胞外容量是血液透析患者发生血管事件的预后因素。
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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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