Atlanto-occipital assimilation: embryological basis and its clinical significance.

IF 1.4 Q3 ANATOMY & MORPHOLOGY
Anatomy & Cell Biology Pub Date : 2024-03-31 Epub Date: 2023-12-20 DOI:10.5115/acb.23.225
Hari Hara Hanusun N, Akanksha Singh, Pooja Poddar, Jessy J P, Neerja Rani, Hitesh Gurjar, Seema Singh
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引用次数: 0

Abstract

Atlanto-occipital assimilation is an osseous embryological anomaly of the craniovertebral junction in which the atlas (C1) is fused to the occiput of skull. Embryologically, this assimilation may happen due to failure of the segmentation and separation of the caudal occipital and the cranial cervical sclerotome. The segmentation clock is maintained by NOTCH and WNT signalling pathways along with Hox genes and retinoic acid. This condition is likely to be a consequence of mutation in above mentioned genes. The knowledge of this assimilation may be crucial for the clinicians as it may lead to various neurovascular symptoms. The present case report involves the analysis of atlanto-occipital assimilation with its clinical significance and embryological basis.

寰枕同化:胚胎学基础及其临床意义。
寰枕同化是颅椎交界处的一种骨性胚胎异常,即寰椎(C1)与头骨枕融合。在胚胎学上,这种同化可能是由于尾枕和颅颈硬骨的分节和分离失败造成的。分节时钟由 NOTCH 和 WNT 信号通路以及 Hox 基因和视黄酸维持。这种情况很可能是上述基因突变的结果。了解这种同化现象对临床医生来说至关重要,因为它可能会导致各种神经血管症状。本病例报告分析了寰枕同位的临床意义和胚胎学基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Anatomy & Cell Biology
Anatomy & Cell Biology ANATOMY & MORPHOLOGY-
CiteScore
1.80
自引率
9.10%
发文量
75
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