Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using solid dispersion and effervescent disintegration technology

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Chao Li, Nanxin Li, Xingyu Chen, Xiaojuan Li, Chang Liu, Awn Abbas, Yueli Wang, Shuangcai Qi, Yifan Zhang, Dongbo Li, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu, Guangneng Peng, Hualin Fu
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引用次数: 0

Abstract

ObjectiveFlorfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability. Significance: Here in, we aimed to explore the applicability of fast disintegrat...
利用固体分散和泡腾崩解技术提高难溶性药物氟苯尼考的溶出率和口服生物利用度
目的:氟苯尼考(FF)是一种优良的兽用抗生素,但溶解性差、生物利用度低。意义在此,我们旨在探索快速分解氟苯尼考的适用性。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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