Unlocking the Anticancer Potential of Ionic Liquids

IF 6.2 3区工程技术 Q1 ENGINEERING, CHEMICAL

ChemBioEng Reviews Pub Date : 2023-12-14 DOI:10.1002/cben.202300051

Najihah Mohd Noor, Ts. Dr. Amal A. M. Elgharbawy, Assoc. Prof. Dr. Muhammad Moniruzzaman, Prof. Masahiro Goto

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Abstract

Despite advances in cancer treatment, many types of cancer still have high mortality rates, and the existing therapies can cause considerable side effects. Therefore, discovering new therapies, especially ones with fewer side effects, is desirable to improve the outcomes for cancer patients. Ionic liquids (ILs) have emerged as potential candidates for cancer treatment because of their particular physicochemical properties, which can be tailored for specific applications. In recent years, interest in exploring the potential of ILs in cancer treatment has been growing, and several studies have demonstrated the effectiveness of ILs in inhibiting cancer-cell growth. This review provides insight into the anticancer potential of ILs, exploring the diverse applications and the underlying mechanisms behind the cytotoxicity toward cancer cells of ILs. Understanding the mechanisms behind the cytotoxicity of ILs can aid in the design and optimization of IL-based cancer therapies. By focusing on specific pathways and targets, IL-based cancer therapies may be developed that offer new possibilities for treating this devastating disease.

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释放离子液体的抗癌潜力

尽管癌症治疗取得了进步，但许多类型的癌症仍然有很高的死亡率，而且现有的治疗方法可能会产生相当大的副作用。因此，发现新的治疗方法，特别是副作用更小的治疗方法，是改善癌症患者预后的理想方法。离子液体(ILs)因其特殊的物理化学性质而成为癌症治疗的潜在候选者，可以针对特定的应用进行定制。近年来，人们对探索il在癌症治疗中的潜力越来越感兴趣，一些研究已经证明了il在抑制癌细胞生长方面的有效性。本文综述了白介素的抗癌潜力，探讨了白介素的多种应用及其对癌细胞的细胞毒性作用机制。了解白细胞介素细胞毒性背后的机制有助于设计和优化基于白细胞介素的癌症治疗方法。通过专注于特定的途径和靶点，基于白介素的癌症疗法可能会被开发出来，为治疗这种毁灭性疾病提供新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemBioEng Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.90

自引率

2.10%

发文量

期刊介绍： Launched in 2014, ChemBioEng Reviews is aimed to become a top-ranking journal publishing review articles offering information on significant developments and provide fundamental knowledge of important topics in the fields of chemical engineering and biotechnology. The journal supports academics and researchers in need for concise, easy to access information on specific topics. The articles cover all fields of (bio-) chemical engineering and technology, e.g.,