In vitro diffusion of plant phenolics through the skin: A review update

IF 2.7 4区 医学 Q2 DERMATOLOGY
Gisláine C. Silva, Rodney A. F. Rodrigues, Carla B. G. Bottoli
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Abstract

Objective

Excessive skin exposure to deleterious environmental variables results in inflammation as well as molecular and cellular impairments that compromise its functionality, aesthetic qualities, and overall well-being. The implementation of topical administration of antioxidants and other compounds as a method for preventing or reversing damage is a rational approach. Numerous phenolic compounds derived from plants have demonstrated capabilities such as scavenging free radicals and promoting tissue healing. However, the primary obstacle lies in effectively delivering these compounds to the specific place on the skin, and accurately forecasting their diffusion through the skin can assist in determining the most effective tactics. Hence, this article provides a comprehensive analysis of recent literature pertaining to the in vitro skin diffusion characteristics of plant phenolics. The aim is to gain a deeper understanding of their behaviour when present in various forms such as solutions, suspensions, and formulations.

Method

The data on plant extracts and isolated plant phenolic compounds in vitro skin diffusion assays published over the last six years were compiled and discussed.

Results

Even though the gold standard Franz diffusion cell is the most commonly used in the assessment of in vitro plant phenolic skin diffusion profiles, a plethora of skin models and assay conditions are reported for a variety of compounds and extracts in different vehicles.

Conclusion

The presence of numerous models and vehicles poses a challenge in creating correlations among the existing data on plant phenolic compounds. However, it is possible to draw some general conclusions regarding molecular, vehicle, and skin characteristics based on the gathered information.

Abstract Image

Abstract Image

植物酚类物质通过皮肤的体外扩散:最新综述
皮肤过度暴露于有害的环境变量会导致炎症以及分子和细胞损伤,从而损害其功能,美学品质和整体健康。局部施用抗氧化剂和其他化合物作为预防或逆转损害的方法是一种合理的方法。许多从植物中提取的酚类化合物已经证明了清除自由基和促进组织愈合的能力。然而,主要的障碍在于有效地将这些化合物输送到皮肤上的特定位置,准确预测它们在皮肤上的扩散可以帮助确定最有效的策略。因此,本文对最近有关植物酚类物质体外皮肤扩散特性的文献进行了全面分析。目的是更深入地了解它们以各种形式存在时的行为,如溶液、悬浮液和配方。
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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
73
期刊介绍: The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
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