Artificial Biomimetic Mineralization of Viruses: More than Calcium

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI:10.1002/anbr.202300064

Pan-Deng Shi, Yan-Peng Xu, Hui Zhao, Cheng-Feng Qin

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Abstract

Biomineralization is a universal biological phenomenon in which organisms use inorganic minerals to form their own structures. Inspired by the discovery of mineralized phages in nature, the concept of artificial biomimetic viral mineralization is proposed and it is validated using a large panel of viruses. Different viruses can be mineralized under different conditions, and the same virus can be completely mineralized using different inorganic minerals. The biomineralized viruses with unique physical and chemical properties display biological phenotypes distinct from those of their native counterparts during the subsequent infection process. These new features are largely due to the inorganic minerals chosen. Calcium is the most frequently used material for viral mineralization, and other inorganic ions, including silicon, aluminum, and ferrum, have also been utilized. In this review, recent advances in the artificial biomimetic mineralization of viruses are summarized while highlighting the potential applications and challenges in biomedicine.

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病毒的人工仿生矿化：不仅仅是钙

生物矿化是一种普遍存在的生物现象，生物利用无机矿物质形成自身的结构。受自然界中矿化噬菌体发现的启发，提出了人工仿生病毒矿化的概念，并使用大量病毒进行了验证。不同的病毒可以在不同的条件下矿化，同一病毒可以使用不同的无机矿物完全矿化。生物矿化病毒具有独特的物理和化学特性，在随后的感染过程中表现出与天然病毒不同的生物表型。这些新特征很大程度上是由于所选择的无机矿物。钙是病毒矿化最常用的材料，其他无机离子，包括硅、铝和铁，也被利用。本文综述了病毒人工仿生矿化的最新研究进展，并重点介绍了其在生物医学领域的潜在应用和面临的挑战。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.