Porous Noble Metal-Based Nanomaterials in Biomedical Applications

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2023-12-03 DOI:10.1002/anbr.202300078

Ziyue Zhang, Shouzhi Yang, Haiyang Su, Kun Qian

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Abstract

Noble metal-based nanomaterials have attracted tremendous attention in biomedical applications due to their unique electrical, optical, and chemical properties, playing crucial roles in the ultrasensitive detection of biomarkers, bioimaging, cancer therapy, etc. Especially, porous noble metal-based nanomaterials show superior performance due to the large specific area and multiple active sites. Platforms constructed from porous noble metal-based nanomaterials are emerging as highly promising tools for various biomedical applications. Herein, the properties and synthesis strategies of porous noble metal-based nanomaterials are briefly introduced. Then the recent progress of porous noble metal-based nanomaterials in the biomedical field is highlighted, focusing primarily on their applications in optics, electrochemistry, and mass spectrometry. Finally, the challenges related to fabrication and biocompatibility for their applications while also providing an outlook on their widespread use in clinical situations are discussed. This review aims to provide further insights into the design of porous noble metal-based nanomaterials and expand their applications in the biomedical field.

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生物医学应用中的多孔贵金属纳米材料

贵金属基纳米材料由于其独特的电学、光学和化学性质，在生物标志物的超灵敏检测、生物成像、癌症治疗等方面发挥着至关重要的作用，在生物医学应用中引起了极大的关注。特别是多孔贵金属基纳米材料，由于其比表面积大、活性位点多，表现出优异的性能。由多孔贵金属基纳米材料构建的平台正在成为各种生物医学应用的非常有前途的工具。本文简要介绍了多孔贵金属基纳米材料的性能和合成策略。然后重点介绍了多孔贵金属基纳米材料在生物医学领域的最新进展，主要集中在光学、电化学和质谱方面的应用。最后，讨论了与制造和生物相容性相关的挑战，同时也展望了它们在临床中的广泛应用。本文旨在为多孔贵金属基纳米材料的设计提供进一步的见解，并扩大其在生物医学领域的应用。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.