Cancer-associated thrombotic microangiopathy; a review article

IF 0.2 Q4 UROLOGY & NEPHROLOGY
Elham Saffarieh, F. Nokhostin, Azadeh Yousefnezhad, Seyedeh Reyhaneh Yousefi Sharemi
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引用次数: 0

Abstract

Cancer-associated thrombotic microangiopathy (TMA) is a rare but is a serious complication that can occur in individuals with malignancy. It is characterized by widespread small blood vessel thrombosis (formation of blood clots) in various organs of the body, leading to organ damage and dysfunction. The exact mechanisms underlying cancer-associated TMA are not fully understood. However, several factors may contribute to its development. Cancer cells can release procoagulant substances that promote blood clot formation, since some tumors can directly invade blood vessels, leading to endothelial cell damage and activation of the coagulation system. Additionally, certain chemotherapeutic agents used in cancer treatment can have adverse effects on the endothelium, further increasing the risk of TMA. Clinically, cancer-associated TMA presents with a range of symptoms depending on the organs affected. Common manifestations include microangiopathic hemolytic anemia, thrombocytopenia, and organ-specific symptoms such as neurological deficits, renal dysfunction, or cardiac abnormalities.
癌症相关血栓性微血管病;综述文章
癌症相关血栓性微血管病(TMA)是一种罕见但严重的并发症,可发生在个体恶性肿瘤。其特点是在身体各器官广泛形成小血管血栓(形成血块),导致器官损伤和功能障碍。癌症相关TMA的确切机制尚不完全清楚。然而,几个因素可能有助于其发展。癌细胞可以释放促凝物质,促进血栓形成,因为一些肿瘤可以直接侵入血管,导致内皮细胞损伤,激活凝血系统。此外,某些用于癌症治疗的化疗药物会对内皮细胞产生不良影响,进一步增加TMA的风险。临床上,癌症相关的TMA表现为一系列症状,取决于受影响的器官。常见的表现包括微血管病性溶血性贫血、血小板减少症和器官特异性症状,如神经功能缺损、肾功能障碍或心脏异常。
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来源期刊
Journal of Renal Injury Prevention
Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-
CiteScore
1.60
自引率
0.00%
发文量
36
期刊介绍: The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.
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