The effectiveness of gabapentin in treating overactive bladder: a quasi-experimental study

IF 1.1 Q4 IMMUNOLOGY
Malik Ayyad, Omar Ayaad, Hassan Alkhatatbeh, F. Sawaqed, Samer Al-Rawashdeh, Bayan Qaddumi
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Abstract

Introduction: Overactive bladder (OAB) is a common condition in urology that affects individuals of various ages and genders, significantly impacting their quality of life. Objectives: The study aimed to examine the effectiveness of gabapentin in treating OAB in Jordan. Patients and Methods: This study was conducted at a private clinic in Jordan between 2020 and 2022. It utilized a one-group pre- and post-test design involving 50 patients. The intervention involved administering gabapentin at a daily dose of 400 mg. The effectiveness of gabapentin was evaluated using the overactive bladder symptom score (OABSS) questionnaire, administered before and after six weeks of gabapentin administration. Results: The study sample consisted of 50 patients aged between 45 and 85 years, with a mean age of 65.2 years. After the treatment, all individual variables, such as urgency, frequency, nocturia, and urgency incontinence, showed significant reductions compared to the pre-intervention values. The mean total OABSS significantly decreased from 14.6 before to 6.8 after the intervention. The paired t test yielded a result of 9.84 with a P value of less than 0.001, indicating a statistically significant improvement. Conclusion: The noteworthy improvement in OABSS scores, urgency, nocturia, frequency of micturition, and urge incontinence observed in this study suggests that gabapentin could have a role as a treatment option for OAB patients.
加巴喷丁治疗膀胱过度活动症的效果:一项准实验研究
膀胱过动症(OAB)是泌尿科的一种常见疾病,可影响不同年龄和性别的个体,严重影响其生活质量。目的:研究加巴喷丁治疗约旦OAB的有效性。患者和方法:本研究于2020年至2022年在约旦的一家私人诊所进行。它采用了一组测试前和测试后的设计,涉及50名患者。干预包括给予加巴喷丁每日400mg的剂量。加巴喷丁的有效性通过膀胱过度活动症状评分(OABSS)问卷进行评估,在加巴喷丁给药前和给药后6周。结果:研究样本包括50例患者,年龄在45 ~ 85岁之间,平均年龄65.2岁。治疗后,所有个体变量,如尿急、尿频、夜尿和尿急失禁,均较干预前显著降低。平均总OABSS由干预前的14.6显著下降至干预后的6.8。配对t检验结果为9.84,P值小于0.001,有统计学意义的改善。结论:本研究中观察到的OABSS评分、尿急、夜尿、排尿频率和急迫性尿失禁的显著改善表明加巴喷丁可以作为OAB患者的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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