Effective Regulation of Auditory Processing by Parvalbumin Interneurons in the Tail of the Striatum

Abstract

Parvalbumin (PV) interneurons in the auditory cortex (AC) play a crucial role in shaping auditory processing, including receptive field formation, temporal precision enhancement, and gain regulation. PV interneurons are also the primary inhibitory neurons in the tail of the striatum (TS), which is one of the major descending brain regions in the auditory nervous system. However, the specific roles of TS-PV interneurons in auditory processing remain elusive. In this study, morphological and slice recording experiments in both male and female mice revealed that TS-PV interneurons, compared to AC-PV interneurons, were present in fewer numbers but exhibited longer projection distances, which enabled them to provide sufficient inhibitory inputs to spiny projection neurons (SPNs). Furthermore, TS-PV interneurons received dense auditory input from both the AC and medial geniculate body (MGB), particularly from the MGB, which rendered their auditory responses comparable to those of AC-PV interneurons. Optogenetic manipulation experiments demonstrated that TS-PV interneurons were capable of bidirectionally regulating the auditory responses of SPNs. Our findings suggest that PV interneurons can effectively modulate auditory processing in the TS and may play a critical role in auditory-related behaviors.Significance StatementPV interneurons are one of the main inhibitory cell types in the TS, even though they are relatively scarce. Currently, it remains unclear whether or to what extent these neurons contribute to auditory processing in the TS. Here, we demonstrated that optogenetic manipulation of PV neuron activity significantly altered the auditory responses of SPNs, providing valuable insights into the role of the TS PV interneurons in auditory processing and their potential role in auditory-related behaviors.