Humoral and Cell-Mediated Responses to SARS-CoV-2 Vaccination in a Cohort of Immunodeficient Patients

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-08 DOI:10.3390/hematolrep15040071

Federica Plano, Mojtaba Shekarkar Azgomi, A. M. Corsale, Corinne Spoto, N. Caccamo, S. Meraviglia, Francesco Dieli, Paolo D’Angelo, A. Trizzino, Sergio Siragusa

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Abstract

This study delves into the intricate landscape of SARS-CoV-2 vaccine response in immunodeficient patients, focusing on the dynamics of both humoral and cell-mediated immunity. The cohort includes patients with common variable immunodeficiency (CVI), agammaglobulinemia (XLA), and combined immunodeficiency (CI). The findings reveal varying degrees of antibody production, with XLA patients exhibiting no measurable response but displaying a robust T-cell-mediated response. The study emphasizes the importance of considering both arms of the immune system in assessing vaccine immunogenicity, particularly in the context of immunodeficiency. The results challenge conventional measures of vaccine efficacy only based on antibody titers, highlighting the need for a more comprehensive understanding of the immune response in this vulnerable population. This research contributes valuable insights to guide clinical decisions regarding vaccination strategies, booster doses, and overall protection in immunodeficient individuals.

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一组免疫缺陷患者对接种 SARS-CoV-2 疫苗的体液和细胞介导反应

本研究深入研究了免疫缺陷患者中SARS-CoV-2疫苗反应的复杂格局，重点关注体液和细胞介导的免疫动力学。该队列包括常见可变免疫缺陷(CVI)、无球蛋白血症(XLA)和联合免疫缺陷(CI)患者。研究结果揭示了不同程度的抗体产生，XLA患者没有可测量的反应，但显示出强大的t细胞介导的反应。该研究强调了在评估疫苗免疫原性时考虑免疫系统的两个分支的重要性，特别是在免疫缺陷的情况下。这一结果挑战了仅基于抗体滴度的疫苗有效性的传统测量方法，强调需要更全面地了解这一易感人群的免疫反应。这项研究为指导免疫缺陷个体的疫苗接种策略、加强剂量和整体保护的临床决策提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.