Review of the demographic factors and toxicology related to deaths due to pregabalin in Northern Ireland

IF 1.2 4区 医学 Q3 MEDICINE, LEGAL
William Ryan Huddleston , James Robert Lyness , Amy Quinn
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引用次数: 0

Abstract

The potential for recreational abuse of the analgesic and antiepileptic drug pregabalin is now well established in the literature. The potential minimum lethal dose in post mortem cases is however less defined. All post mortem examinations in Northern Ireland where the cause of death was found to be due to pregabalin were examined for demographic and toxicological analysis. Deaths are generally seen in young men, especially 30-39-year-olds, many of whom have a history of substance misuse and are often prescribed pregabalin. Until recently, prescription rates have been on the rise regionally. The overall median post mortem peripheral blood concentration of pregabalin found in this study is 10.6 mg/L, however this rises when concurrent drugs and alcohol are considered and in cases where pregabalin is considered responsible for death alone (i.e. outside of multidrug toxicity). Pregabalin peripheral blood concentrations returned in this study suggest previously offered minimum lethal dosages may need to be revised downward.

北爱尔兰普瑞巴林致死事件相关人口学因素和毒理学回顾
镇痛和抗癫痫药物普瑞巴林可能会被娱乐性滥用,这一点现已在文献中得到充分证实。然而,死后病例中潜在的最低致死剂量却不太明确。我们对北爱尔兰所有发现死因是普瑞巴林的尸检病例进行了人口统计学和毒理学分析。死亡病例通常发生在年轻男性身上,尤其是 30-39 岁的年轻人,他们中的许多人都有药物滥用史,并经常被处方普瑞巴林。直到最近,处方率在地区范围内一直呈上升趋势。本研究发现的普瑞巴林死后外周血浓度总体中位数为 10.6 毫克/升,但如果考虑到同时服用的药物和酒精,以及普瑞巴林被认为是导致单独死亡的原因(即多种药物毒性之外的原因),这一中位数会有所上升。本研究中返回的普瑞巴林外周血浓度表明,以前提供的最小致死剂量可能需要下调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
6.70%
发文量
106
审稿时长
57 days
期刊介绍: The Journal of Forensic and Legal Medicine publishes topical articles on aspects of forensic and legal medicine. Specifically the Journal supports research that explores the medical principles of care and forensic assessment of individuals, whether adult or child, in contact with the judicial system. It is a fully peer-review hybrid journal with a broad international perspective. The Journal accepts submissions of original research, review articles, and pertinent case studies, editorials, and commentaries in relevant areas of Forensic and Legal Medicine, Context of Practice, and Education and Training. The Journal adheres to strict publication ethical guidelines, and actively supports a culture of inclusive and representative publication.
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