Acetazolamide and human carbonic anhydrases: retrospect, review and discussion of an intimate relationship

IF 5.6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Enzyme Inhibition and Medicinal Chemistry Pub Date : 2023-12-11 DOI:10.1080/14756366.2023.2291336

Dimitrios Tsikas

引用次数: 0

Abstract

Acetazolamide (AZM) is a strong pharmacological sulphonamide-type (R-SO2-NH2, pKa 7.2) inhibitor of the activity of several carbonic anhydrase (CA) isoforms, notably of renal CA II (Ki, 12 nM) and ...

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乙酰唑胺和人体碳酸酐酶：亲密关系的回顾、评述和讨论

乙酰唑胺（AZM）是一种强效药理磺酰胺类（R-SO2-NH2，pKa 7.2）抑制剂，可抑制多种碳酸酐酶（CA）同工酶的活性，尤其是肾脏CA II（Ki，12 nM）和...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Enzyme Inhibition and Medicinal Chemistry 医学-生化与分子生物学

CiteScore

10.30

自引率

10.70%

发文量

195

审稿时长

4-8 weeks

期刊介绍： Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research. The journal’s focus includes current developments in: Enzymology; Cell biology; Chemical biology; Microbiology; Physiology; Pharmacology leading to drug design; Molecular recognition processes; Distribution and metabolism of biologically active compounds.