Increased accumulation of the advanced glycation endproduct Ne(carboxymethyl) lysine in the intramyocardial vasculature in patients with epicarditis

IF 1.8 4区医学 Q3 PATHOLOGY

International Journal of Experimental Pathology Pub Date : 2023-12-08 DOI:10.1111/iep.12499

U Baylan, A Baidoshvili, S Simsek, CG Schalkwijk, HWM Niessen, PAJ Krijnen

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Abstract

Advanced glycation end-products (AGEs) are implicated in the pathogenesis of vascular disease. In previous studies we have found increased deposition of N(e)-(carboxymethyl)lysine (CML) in intramyocardial vasculature in the heart in acute myocardial infarction and myocarditis. It is known that the process of inflammation plays a role in the formation of AGEs. In this study we have explored the presence of CML (a major AGE) in the heart of patients with epicarditis using a monoclonal anti-CML antibody. Nine patients with epicarditis (n = 9) died and their hearts were used for this study, control were hearts from patients who died from conditions unrelated to heart disease and without signs of myocarditis or epicarditis CML deposition and complement were significantly increased in patients with epicarditis compared to control hearts. Thus epicarditis increases CML depositions in the intramyocardial vasculature.

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心外膜炎患者心内血管中的高级糖化终产物氖（羧甲基）赖氨酸积累增加

高级糖化终产物（AGEs）与血管疾病的发病机制有关。在之前的研究中，我们发现急性心肌梗塞和心肌炎患者的心脏心内血管中 N（e）-（羧甲基）赖氨酸（CML）沉积增加。众所周知，炎症过程在 AGEs 的形成过程中起着一定的作用。在这项研究中，我们使用单克隆抗 CML 抗体检测了心外膜炎患者心脏中是否存在 CML（一种主要的 AGE）。九名心外膜炎患者（n = 9）死亡，他们的心脏被用于本研究，对照组是死于与心脏病无关的疾病且无心肌炎或心外膜炎症状的患者的心脏。与对照组心脏相比，心外膜炎患者的 CML 沉积和补体明显增加。因此，心外膜炎会增加 CML 在心内血管中的沉积。

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来源期刊

International Journal of Experimental Pathology 医学-病理学

CiteScore

4.50

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes. The International Journal of Experimental Pathology - IJEP - publishes papers which afford new and imaginative insights into the basic mechanisms underlying human disease, including in vitro work, animal models, and clinical research. Aiming to report on work that addresses the common theme of mechanism at a cellular and molecular level, IJEP publishes both original experimental investigations and review articles. Recent themes for review series have covered topics as diverse as "Viruses and Cancer", "Granulomatous Diseases", "Stem cells" and "Cardiovascular Pathology".