Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2023-12-07 DOI:10.1016/j.cellimm.2023.104796

Youssouf Sereme , Eya Toumi , Estelle Saifi , Helène Faury , David Skurnik

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引用次数: 0

Abstract

Newborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells.

Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impacting immune development and the establishment of immune tolerance.

In this context, maternal vaccination is a powerful tool to enhance even more maternal and neonatal health. It involves the transfer of vaccine-induced antibodies to protect both mother and child from infectious diseases.

In this work we review the state of the art on maternal immune factors involved in the prevention of neonatal bacterial infections, with particular emphasis on the role of maternal vaccination in protecting neonates against bacterial disease.

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预防或促进新生儿细菌感染的母体免疫因素

无论是早产儿还是足月儿，新生儿的免疫系统已经完全形成，但仍处于幼稚状态，必须适应宫外环境以防止感染。通过胎盘和母乳传播的母体免疫主要通过免疫球蛋白（IgG 和 IgA）和某些母体免疫细胞（也称为微嵌合细胞）保护新生儿免受感染。最近，母体肠道微生物群通过微生物化合物影响免疫发育和免疫耐受的建立，在新生儿免疫成熟过程中发挥着重要作用。在这项工作中，我们回顾了母体免疫因素在预防新生儿细菌感染方面的最新进展，特别强调了母体疫苗接种在保护新生儿免受细菌疾病侵害方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.