Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Pub Date : 2023-12-07 DOI:10.1134/s0026893323060067

R. G. Goncharov, M. G. Sharapov

引用次数: 0

Abstract—Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially significant diseases as stroke, myocardial infarction, acute renal failure, etc. The present review considers modern ideas about the main biochemical and signal-regulatory processes in the cell under conditions of ischemia–reperfusion. Both generally accepted and newly developed ways of ischemia–reperfusion lesion correction aimed at different chains of this pathological process are considered.

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缺血再灌注损伤：发病的分子机制及其纠正方法

摘要--缺血再灌注是许多人类疾病（包括中风、心肌梗塞、急性肾功能衰竭等具有重大社会意义的疾病）的一连串复杂而又相互关联的病理过程。本综述探讨了缺血再灌注条件下细胞内主要生化和信号调节过程的现代观点。针对这一病理过程的不同环节，还考虑了普遍接受的和新开发的缺血再灌注病变矫正方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology 生物-生化与分子生物学

CiteScore

1.30

自引率

8.30%

发文量

审稿时长

3 months

期刊介绍： Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.