Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2023-10-01 DOI:10.1016/j.ghir.2023.101561

Tathyana Benetis Piau, Aline de Queiroz Rodrigues, Fernanda Paulini

{"title":"Insulin-like growth factor (IGF) performance in ovarian function and applications in reproductive biotechnologies","authors":"Tathyana Benetis Piau, Aline de Queiroz Rodrigues, Fernanda Paulini","doi":"10.1016/j.ghir.2023.101561","DOIUrl":null,"url":null,"abstract":"<div>The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiation and apoptosis. Considering the importance of IGFs in oocyte maturation, this review sought to elucidate aspects including: IGF production mechanisms; constituent members of their family and their respective functions; the role that these factors play during folliculogenesis, together with their functions during oocyte maturation and apoptosis, and their performance during luteal development. This review also explores the role of IGFs in biotechnological applications, focusing specifically on animal genetic gain.</div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":"72 ","pages":"Article 101561"},"PeriodicalIF":1.6000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637423000394","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiation and apoptosis. Considering the importance of IGFs in oocyte maturation, this review sought to elucidate aspects including: IGF production mechanisms; constituent members of their family and their respective functions; the role that these factors play during folliculogenesis, together with their functions during oocyte maturation and apoptosis, and their performance during luteal development. This review also explores the role of IGFs in biotechnological applications, focusing specifically on animal genetic gain.

查看原文本刊更多论文

胰岛素样生长因子（IGF）在卵巢功能中的表现及在生殖生物技术中的应用

胰岛素样生长因子（IGF）系统的作用引起了人们的密切关注。迄今为止，IGF 结合蛋白（IGFBPs）在卵巢中的活性尚未完全阐明。这些蛋白与 IGF 的结合亲和力与 IGF1 受体的结合亲和力相同或更高，因此，除了延长 IGF 在血液中的半衰期和促进 IGF 在特定组织龛位中的储存外，它们还处于调节 IGF 信号的主要位置。IGF1 在细胞增殖、分化和凋亡中发挥着重要作用。考虑到 IGFs 在卵母细胞成熟过程中的重要性，本综述试图阐明包括以下方面在内的问题：IGF 的产生机制；IGF 家族的组成成员及其各自的功能；这些因子在卵泡生成过程中的作用，以及它们在卵母细胞成熟和凋亡过程中的功能和它们在黄体发育过程中的表现。本综述还探讨了 IGF 在生物技术应用中的作用，尤其侧重于动物基因增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.