An Enviromentally Sensitive Zinc-Selective Two-Photon NIR Fluorescent Turn-on probe And Zinc sensing In Stroke

IF 6.1 1区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Analysis Pub Date : 2023-11-29 DOI:10.1016/j.jpha.2023.11.010

Junfeng Wang, Qibing Liu, Yingbo Li, Yi Pang

引用次数: 0

Abstract

A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and sensitivity for Zn²⁺ detection has been developed. This sensor exhibits a large Stokes' shift (∼300 nm) and can be excited from 900 to 1000 nm, with an emission wavelength of ∼785 nm, making it ideal for imaging in biological tissues. The sensor's high selectivity for Zn²⁺ over other structurally similar cations, such as Cd²⁺, makes it a promising tool for monitoring zinc ion levels in biological systems. Given the high concentration of zinc in thrombi, this sensor could provide a useful tool for in vivo thrombus imaging.

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一种环境敏感的锌选择双光子近红外荧光开启探针和中风中的锌传感

研制了一种高选择性、高灵敏度的双光子近红外荧光开启传感器，用于检测Zn2+。该传感器具有较大的斯托克斯位移(~ 300 nm)，可以在900 ~ 1000 nm范围内激发，发射波长为~ 785 nm，使其成为生物组织成像的理想选择。该传感器对Zn2+的高选择性优于其他结构相似的阳离子，如Cd2+，使其成为监测生物系统中锌离子水平的有前途的工具。鉴于血栓中锌的高浓度，该传感器可以为血栓的体内成像提供有用的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmaceutical Analysis Chemistry-Electrochemistry

CiteScore

16.20

自引率

2.30%

发文量

674

审稿时长

22 weeks

期刊介绍： The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University. JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.