Histopathological evaluation of amino acid capped silver nanoconjugates in albino mice

IF 1.3 4区工程技术 Q4 ENGINEERING, BIOMEDICAL

Bioinspired Biomimetic and Nanobiomaterials Pub Date : 2021-12-22 DOI:21.00033

Sarwar Allah Ditta, Atif Yaqub, Fouzia Tanvir, Rehan Ullah, Muhammad Rashid, Muhammad Bilal

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Abstract

Various molecules may modify the surface chemistry of commonly used nanomaterials (NMs), resulting in the synthesis of novel and safer NMs. The current study was delineated to evaluate the in vivo toxicity profiling of the silver nanoconjugates (AgNCs) conjugated with different amino acids. The L-glycine capped-AgNCs exhibited toxicity and caused tissue damage, while L-cystine- and L-tyrosine-capped AgNCs showed protective effects against cadmium-induced toxicity. L-cystine-capped AgNCs performed well as compared to other amino-acid AgNCs. The level of serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and blood urea increased (p < 0.05) in G2, G3 and G5 in comparison to G1 (control group), while an increase in bilirubin for G2 was statistically non-significant (p > 0.05). The ALT and AST elevated (p < 0.05) in G4; however, other serological parameters in G4 and G6 did not show any noticeable change in their values. Histological analysis showed disturbed and deformed cellular structures in liver and kidney tissues of G2, G3 and G5. However, G4 and G6 samples demonstrated minute changes in comparison to G1. It is concluded that L-cystine- and L-tyrosine-capped AgNCs exhibited protective effects and should be tested further for developing safer nanoconjugates for biomedical uses.

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氨基酸覆盖银纳米偶联物在白化病小鼠中的组织病理学评价

各种分子可以修饰常用纳米材料的表面化学性质，从而合成新的、更安全的纳米材料。本研究旨在评价不同氨基酸偶联银纳米偶联物(agnc)的体内毒性。l -甘氨酸包盖的AgNCs表现出毒性并引起组织损伤，而l -胱氨酸和l -酪氨酸包盖的AgNCs对镉诱导的毒性表现出保护作用。与其他氨基酸agnc相比，l -胱氨酸封顶agnc表现良好。血清肌酐、谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶和血尿素水平升高(p <与G1(对照组)相比，G2、G3和G5的胆红素升高无统计学意义(p >0.05)。ALT和AST升高(p <0.05);而G4、G6的其他血清学参数无明显变化。组织学分析显示G2、G3和G5的肝、肾组织细胞结构紊乱和变形。然而，与G1相比，G4和G6样品表现出微小的变化。综上所述，l -胱氨酸和l -酪氨酸覆盖的agnc具有保护作用，应该进一步测试以开发用于生物医学用途的更安全的纳米偶联物。

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来源期刊

Bioinspired Biomimetic and Nanobiomaterials ENGINEERING, BIOMEDICAL-MATERIALS SCIENCE, BIOMATERIALS

CiteScore

2.20

自引率

0.00%

发文量

期刊介绍： Bioinspired, biomimetic and nanobiomaterials are emerging as the most promising area of research within the area of biological materials science and engineering. The technological significance of this area is immense for applications as diverse as tissue engineering and drug delivery biosystems to biomimicked sensors and optical devices. Bioinspired, Biomimetic and Nanobiomaterials provides a unique scholarly forum for discussion and reporting of structure sensitive functional properties of nature inspired materials.