Neuronal activity in posterior parietal cortex area LIP is not sufficient for saccadic eye movement production

IF 2.6 3区医学 Q2 BEHAVIORAL SCIENCES

Frontiers in Integrative Neuroscience Pub Date : 2023-11-24 DOI:10.3389/fnint.2023.1251431

Emiliano Brunamonti, Martin Paré

引用次数: 0

Abstract

It is widely recognized that the posterior parietal cortex (PPC) plays a role in active exploration with eye movements, arm reaching, and hand grasping. Whether this role is causal in nature is largely unresolved. One region of the PPC appears dedicated to the control of saccadic eye movement—lateral intraparietal (LIP) area. This area LIP possesses direct projections to well-established oculomotor centers and contains neurons with movement-related activity. In this study, we tested whether these neurons are implicated in saccade initiation and production. The movement-related activity of LIP neurons was tested by recording these neurons while monkeys performed a countermanding task. We found that LIP neuronal activity is not different before the execution or the cancelation of commanded saccades and thereby is not sufficient for the initiation and production of saccades. Consistent with the evolutionarily late emergence of the PPC, this finding relegates the role of this PPC area to processes that can regulate but not trigger eye movements.

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后顶叶区(LIP)的神经元活动不足以产生跳眼眼动

人们普遍认为，后顶叶皮层(PPC)在眼球运动、手臂伸展和手抓握等主动探索活动中起着重要作用。这种作用在本质上是否具有因果关系在很大程度上尚未解决。PPC的一个区域似乎专门用于控制跳眼运动-顶叶内侧区(LIP)。这一区域具有直接投射到成熟的动眼肌中枢，并包含与运动相关的神经元。在这项研究中，我们测试了这些神经元是否与扫视的发生和产生有关。在猴子执行反命令任务时，通过记录这些神经元来测试LIP神经元的运动相关活动。我们发现，在执行或取消指令扫视之前，LIP神经元的活动并没有什么不同，因此并不足以引发和产生扫视。与PPC在进化上出现较晚一致，这一发现将该PPC区域的作用归为可以调节但不触发眼球运动的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience

CiteScore

4.60

自引率

2.90%

发文量

148

审稿时长

14 weeks

期刊介绍： Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.