Redox-Neutral Decarboxylative Cross-Coupling of Oxamates with Aryl Bromides

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY
Akash Bisoyi, Vijay Kumar Simhadri, Surya K, Rositha Kuniyil* and Veera Reddy Yatham*, 
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引用次数: 0

Abstract

Dual nickel-photoredox-enabled direct synthesis of amides through cross-coupling of cesium oxamates with aryl bromides has been developed. This methodology’s key advantages are mild reaction conditions, utilizing organic dye as a photocatalyst, employing readily available starting chemicals as coupling partners, and late-stage carbamoylation of pharmaceutically relevant molecules. DFT studies suggested that the nickel catalytic cycle proceeds via a radical addition pathway prior to the oxidative insertion.

Abstract Image

Abstract Image

草酸盐与芳基溴的氧化还原-中性脱羧交偶联
研究了双镍光氧化还原直接合成草酸铯与芳基溴交叉偶联酰胺的方法。该方法的主要优点是温和的反应条件,利用有机染料作为光催化剂,使用现成的起始化学品作为偶联伙伴,以及后期药物相关分子的氨基甲酰化。DFT研究表明,镍的催化循环在氧化插入之前通过自由基加成途径进行。
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来源期刊
ACS Organic & Inorganic Au
ACS Organic & Inorganic Au 有机化学、无机化学-
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.
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