{"title":"Survivin as a potential biomarker for early diagnosis of the progression of precancerous lesions to gastric cancer.","authors":"Amirreza Mahmoudzadeh-Sagheb, Mehran Panahi, Setareh Jami, Bita Moudi, Hamidreza Mahmoudzadeh-Sagheb, Zahra Heidari","doi":"10.1177/03936155231217268","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer is a common cancer developed in a carcinogenesis process from precancerous lesions including chronic gastritis, intestinal metaplasia, and dysplasia. Survivin, an inhibitor-of-apoptosis protein, is associated with the initiation and progression of gastric cancer. The present study aimed to evaluate the immunohistochemical expression patterns of survivin and its relationship with early diagnosis of gastric cancer in Iranian patients.</p><p><strong>Methods: </strong>In this retrospective case-control study, immunoexpression of survivin was investigated on sections obtained from formalin-fixed paraffin-embedded tissue blocks of 38 chronic gastritis, 32 intestinal metaplasia, 20 dysplasia, 28 gastric adenocarcinoma, and 22 controls.</p><p><strong>Results: </strong>Survivin immunoexpression in chronic gastritis was higher than controls, but this difference was not statistically significant (<i>P</i> > 0.05). However, survivin immunoexpression had a steady significant increase from control and chronic gastritis to intestinal metaplasia to dysplasia to gastric adenocarcinoma (<i>P</i> < 0.05). Sensitivity, specificity, and area under the curve of survivin immunohistochemical test for the diagnosis of gastric cancer were 87.5%, 74.4%, and 0.85, respectively. Males had a significantly higher survivin expression than females (<i>P</i> < 0.001). Also, survivin expression was significantly higher in older patients than in younger ones (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>It seems that the steady increase in survivin expression from different precancerous lesions to gastric adenocarcinoma suggests that survivin can be used as a potential biomarker for the prevention and early diagnosis of gastric cancer.</p>","PeriodicalId":50334,"journal":{"name":"International Journal of Biological Markers","volume":" ","pages":"52-58"},"PeriodicalIF":2.3000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biological Markers","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03936155231217268","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Gastric cancer is a common cancer developed in a carcinogenesis process from precancerous lesions including chronic gastritis, intestinal metaplasia, and dysplasia. Survivin, an inhibitor-of-apoptosis protein, is associated with the initiation and progression of gastric cancer. The present study aimed to evaluate the immunohistochemical expression patterns of survivin and its relationship with early diagnosis of gastric cancer in Iranian patients.
Methods: In this retrospective case-control study, immunoexpression of survivin was investigated on sections obtained from formalin-fixed paraffin-embedded tissue blocks of 38 chronic gastritis, 32 intestinal metaplasia, 20 dysplasia, 28 gastric adenocarcinoma, and 22 controls.
Results: Survivin immunoexpression in chronic gastritis was higher than controls, but this difference was not statistically significant (P > 0.05). However, survivin immunoexpression had a steady significant increase from control and chronic gastritis to intestinal metaplasia to dysplasia to gastric adenocarcinoma (P < 0.05). Sensitivity, specificity, and area under the curve of survivin immunohistochemical test for the diagnosis of gastric cancer were 87.5%, 74.4%, and 0.85, respectively. Males had a significantly higher survivin expression than females (P < 0.001). Also, survivin expression was significantly higher in older patients than in younger ones (P < 0.001).
Conclusion: It seems that the steady increase in survivin expression from different precancerous lesions to gastric adenocarcinoma suggests that survivin can be used as a potential biomarker for the prevention and early diagnosis of gastric cancer.
背景:胃癌是一种常见的癌前病变，包括慢性胃炎、肠化生和不典型增生。Survivin是一种抑制细胞凋亡的蛋白，与胃癌的发生和发展有关。本研究旨在探讨survivin免疫组化表达模式及其与伊朗胃癌早期诊断的关系。方法:在回顾性病例对照研究中，对38例慢性胃炎、32例肠化生、20例非典型增生、28例胃腺癌和22例对照组的福尔马林固定石蜡包埋组织块切片进行survivin的免疫表达研究。结果:慢性胃炎患者Survivin免疫表达高于对照组，但差异无统计学意义(P > 0.05)。而survivin的免疫表达在对照组和慢性胃炎、肠化生、异型增生、胃腺癌中呈稳定的显著升高(P P P P)。结论:survivin在不同癌前病变到胃腺癌中的表达稳定升高，提示survivin可作为胃癌预防和早期诊断的潜在生物标志物。
期刊介绍：
IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.
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