Integrating osteoimmunology and nanoparticle-based drug delivery systems for enhanced fracture healing

IF 4.2 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2023-12-04 DOI:10.1016/j.nano.2023.102727

Baixue Xiao PhD , Emmanuela Adjei-Sowah MS , Danielle S.W. Benoit PhD

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引用次数: 0

Abstract

Fracture healing is a complex interplay of molecular and cellular mechanisms lasting from days to weeks. The inflammatory phase is the first stage of fracture healing and is critical in setting the stage for successful healing. There has been growing interest in exploring the role of the immune system and novel therapeutic strategies, such as nanoparticle drug delivery systems in enhancing fracture healing. Advancements in nanotechnology have revolutionized drug delivery systems to the extent that they can modulate immune response during fracture healing by leveraging unique physiochemical properties. Therefore, understanding the intricate interactions between nanoparticle-based drug delivery systems and the immune response, specifically macrophages, is essential for therapeutic efficacy. This review provides a comprehensive overview of the relationship between the immune system and nanoparticles during fracture healing. Specifically, we highlight the influence of nanoparticle characteristics, such as size, surface properties, and composition, on macrophage activation, polarization, and subsequent immune responses.

Impact statement

This review provides valuable insights into the interplay between fracture healing, the immune system, and nanoparticle-based drug delivery systems. Understanding nanoparticle-macrophage interactions can advance the development of innovative therapeutic approaches to enhance fracture healing, improve patient outcomes, and pave the way for advancements in regenerative medicine.

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整合骨免疫学和纳米颗粒为基础的药物输送系统，促进骨折愈合。

骨折愈合是一个复杂的相互作用的分子和细胞机制持续数天至数周。炎症期是骨折愈合的第一阶段，是为骨折成功愈合奠定基础的关键阶段。人们对探索免疫系统和新型治疗策略的作用越来越感兴趣，例如纳米颗粒药物输送系统在促进骨折愈合方面的作用。纳米技术的进步已经彻底改变了药物输送系统，它们可以通过利用独特的物理化学特性来调节骨折愈合过程中的免疫反应。因此，了解基于纳米颗粒的药物传递系统与免疫反应(特别是巨噬细胞)之间复杂的相互作用对于治疗效果至关重要。本文综述了在骨折愈合过程中免疫系统和纳米颗粒之间的关系。具体来说，我们强调纳米颗粒的特性，如大小、表面性质和组成，对巨噬细胞活化、极化和随后的免疫反应的影响。影响声明:本综述为骨折愈合、免疫系统和基于纳米颗粒的药物传递系统之间的相互作用提供了有价值的见解。了解纳米颗粒-巨噬细胞的相互作用可以促进创新治疗方法的发展，以增强骨折愈合，改善患者的治疗效果，并为再生医学的进步铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.