Chemical Structures

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Heterocycles Pub Date : 2023-11-24 DOI:10.3987/com-23-14924

引用次数: 0

Abstract

From the peels of Citrus sphaerocarpa, two new limonoids, sphaerocarpain Ⅰ and Ⅱ were isolated together with five known compounds including methyl deacetylnomilinate and ichangin. The chemical structures of the new compounds were elucidated based on chemical/physicochemical evidence. For sphaerocarpain Ⅰ and Ⅱ, the absolute configuration was established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, sphaerocarpain I, II, methyl deacetylnomilinate and ichangin showed cytotoxic activity against both human neuroblastoma cells (SH-SY5Y) and human glioblastoma cells (U-251 MG).

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化学结构

从柑橘皮中分离到两个新的类柠檬素，分别为sphaerocarpaⅠ和Ⅱ，并分离到5个已知化合物，包括甲基去乙酰氨基酸酯和changin。根据化学/物理化学证据对新化合物的化学结构进行了分析。对于球形carpainⅠ和Ⅱ，通过比较实验和预测的电子圆二色性(ECD)数据，建立了绝对构型。在分离的化合物中，sphaerocarpain I、II、去乙酰氨基磺酸甲酯和changin对人神经母细胞瘤细胞(SH-SY5Y)和人胶质母细胞瘤细胞(U-251 MG)均有细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocycles 化学-有机化学

CiteScore

1.50

自引率

0.00%

发文量

108

审稿时长

1 months

期刊介绍： Since its inception in 1973 HETEROCYCLES has provided a platform for the rapid exchange of research in the areas of organic, pharmaceutical, analytical, and medicinal chemistry of heterocyclic compounds in addition to communications, papers, reviews, a special section of the journal presents newly-discovered natural products whose structure has recently been established. Another section is devoted to the total synthesis of previously documented natural products with heterocyclic ring systems. Due to the fact that the journal is able to publish articles within two months of receipt of the manuscripts, researchers in this field can obtain up-to-date information on heterocyclic research by reading Heterocycles regularly. Audience: Organic and Physical Organic Chemists, Biochemists, Pharmacologists and Scientists studying heterocyclic compounds

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