Diterpene Glycosides Derived from

Abstract

Senescence-associated secretory phenotype (SASP) factors, involved in inflammation and tumorigenesis, can be inhibited by CD39, which degrades extracellular ATP. In this study, we analysed the chemical composition of the extracts of Aster spathulifolius, a coastal medicinal plant belonging to the Asteraceae family, and thereafter, isolated and determined the structures of the active components. We also treated THP-1 cells with the A. spathulifolius extracts and observed CD39 expression. Nine secondary metabolites, including a new diterpene glycoside 1, were isolated. Compounds 1 and 3–7 substantially promoted CD39 expression in THP-1 cells, and compound 3, the abundant component, showed the strongest effect in this regard, possibly degrading ATP and inhibiting the SASP.