Microbial Primer: In vivo biofilm.

IF 2.6 4区 生物学 Q3 MICROBIOLOGY
Kendra P Rumbaugh, Thomas Bjarnsholt
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引用次数: 0

Abstract

In this primer on biofilms and their role in infections, we trace the historical roots of microbial understanding from Van Leeuwenhoek's observations to Bill Costerton's groundbreaking work, which solidified biofilms' significance in infections. In vivo biofilm research, investigating patient samples and utilizing diverse host models, has yielded invaluable insights into these complex microbial communities. However, it comes with several challenges, particularly regarding replicating biofilm infections accurately in the laboratory. In vivo biofilm analyses involve various techniques, revealing biofilm architecture, composition, and behaviour, while gaps in knowledge persist regarding infection initiation and source, diversity, and the Infectious Microenvironment (IME). Ultimately, the study of biofilms in infections remains a dynamic and evolving field poised to transform our approach to combat biofilm-associated diseases.

微生物入门:体内生物膜。
在这本关于生物膜及其在感染中的作用的入门读物中,我们追溯了从范-列文虎克(Van Leeuwenhoek)的观察到比尔-科斯特顿(Bill Costerton)的开创性工作等微生物认识的历史根源,这些工作巩固了生物膜在感染中的重要性。体内生物膜研究通过调查病人样本和利用不同的宿主模型,对这些复杂的微生物群落产生了宝贵的见解。然而,这项研究也面临着一些挑战,尤其是在实验室中准确复制生物膜感染方面。体内生物膜分析涉及各种技术,揭示了生物膜的结构、组成和行为,而在感染的起始和来源、多样性和感染微环境(IME)方面的知识仍然存在差距。归根结底,对感染中生物膜的研究仍是一个充满活力、不断发展的领域,有望改变我们对抗生物膜相关疾病的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbiology-Sgm
Microbiology-Sgm 生物-微生物学
CiteScore
4.60
自引率
7.10%
发文量
132
审稿时长
3.0 months
期刊介绍: We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms. Topics include but are not limited to: Antimicrobials and antimicrobial resistance Bacteriology and parasitology Biochemistry and biophysics Biofilms and biological systems Biotechnology and bioremediation Cell biology and signalling Chemical biology Cross-disciplinary work Ecology and environmental microbiology Food microbiology Genetics Host–microbe interactions Microbial methods and techniques Microscopy and imaging Omics, including genomics, proteomics and metabolomics Physiology and metabolism Systems biology and synthetic biology The microbiome.
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