No benefit of soluble fiber on liver function.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Abed Ghavami, Sepide Talebi, Hanieh Barghchi, Elyas Nattagh-Eshtivani, Hamed Mohammadi, Rahele Ziaei
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引用次数: 0

Abstract

Background: To conduct a systematic review and dose-response meta-analysis of current findings from randomized controlled trials (RCTs) on the effect of soluble fiber supplementation on liver function in both healthy individuals and people with specific health conditions, PubMed, Scopus, and ISI Web of Science were systematically searched for relevant RCTs published prior to April 2022. Methods: We estimated the change in liver function parameters for each 5 g/d increment in soluble fiber in each trial and then calculated the mean difference (MD) and 95%CI. A total of 25 RCTs with 27 treatment arms (1744 subjects; 884 cases, 860 controls) were included. Results: A total of 25 RCTs with 27 treatment arms were included. The intervention duration of the included studies ranged from 3 to 52 weeks and the dose of soluble fiber supplementation varied from 0.0025 to 40 g/d. Soluble fiber supplementation could not significantly affect serum alanine transaminase (MD: -0.02 U/L, 95% CI: -1.06 to 1.01), aspartate transaminase (MD: -0.34 U/L, 95% CI: -0.84 to 0.15), alkaline phosphatase (MD: 0.29 U/L, -0.14 to 0.71), gamma-glutamyl transferase (MD: 0.12 U/L; 95% CI: -0.81 to 1.05), serum bilirubin (MD: 0.42μmol/L, 95% CI: -0.08 to 0.93) and albumin (MD: 0.64 g/dl, 95% CI: -0.42 to 1.70) levels. Conclusions: Findings from this study did not support the beneficial effects of soluble fiber supplementation on liver function biomarkers. There is a need for long-term high-quality interventions to examine the effects of different types and doses of soluble fibers on liver function as primary outcome.

可溶性纤维对肝功能没有好处。
背景:为了对随机对照试验(rct)中关于可溶性纤维补充剂对健康个体和特定健康状况人群肝功能影响的研究结果进行系统评价和剂量反应荟萃分析,PubMed、Scopus和ISI Web of Science系统检索了2022年4月之前发表的相关rct。方法:我们估计每个试验中可溶性纤维每增加5 g/d,肝功能参数的变化,然后计算平均差值(MD)和95%CI。共有25项随机对照试验,27个治疗组(1744名受试者;共纳入884例(对照组860例)。结果:共纳入25项随机对照试验,共27个治疗组。纳入研究的干预持续时间为3至52周,可溶性纤维补充剂量为0.0025至40 g/d。可溶性纤维补充对血清丙氨酸转氨酶(MD: -0.02 U/L, 95% CI: -1.06 ~ 1.01)、天冬氨酸转氨酶(MD: -0.34 U/L, 95% CI: -0.84 ~ 0.15)、碱性磷酸酶(MD: 0.29 U/L, -0.14 ~ 0.71)、γ -谷氨酰转移酶(MD: 0.12 U/L;95% CI: -0.81 ~ 1.05),血清胆红素(MD: 0.42μmol/L, 95% CI: -0.08 ~ 0.93)和白蛋白(MD: 0.64 g/dl, 95% CI: -0.42 ~ 1.70)水平。结论:本研究结果不支持补充可溶性纤维对肝功能生物标志物的有益作用。需要长期高质量的干预措施来检验不同类型和剂量的可溶性纤维对肝功能的影响,作为主要结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
4.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds. The editorial and advisory boards include many of the leading persons currently working in this area. The journal is of particular interest to: - Nutritionists - Vitaminologists - Biochemists - Physicians - Engineers of human and animal nutrition - Food scientists
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