Molecular mechanisms of cellular metabolic homeostasis in stem cells.

IF 10.8 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Xiaoyu Li, Ou Jiang, Songlin Wang
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引用次数: 0

Abstract

Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.

Abstract Image

干细胞细胞代谢稳态的分子机制。
许多组织和器官系统具有内在的再生能力,这在很大程度上是由组织驻留干细胞群驱动和维持的。近年来,越来越多的证据表明,细胞代谢稳态在调节干细胞命运、组织再生和稳态中起着核心作用。因此,对调节干细胞代谢稳态的机制的透彻理解可能有助于我们了解组织稳态是如何维持的,并为疾病管理提供新的见解。在这篇综述中,我们总结了已知的干细胞代谢稳态调节与分子通路之间的关系。我们还讨论了代谢稳态在疾病治疗中的潜在靶点,并描述了这些新的治疗靶点目前的局限性和未来的发展方向。
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来源期刊
International Journal of Oral Science
International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
31.80
自引率
1.30%
发文量
53
审稿时长
>12 weeks
期刊介绍: The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.
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