Reproducibility and responsiveness of airway impedance measures derived from the forced oscillation technique across different operating lung volumes

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-11-28 DOI:10.1016/j.resp.2023.104200

Craig R. Aitken , Girish Pathangey , Mathew Stamos , Chul-Ho Kim , Bruce D. Johnson , Glenn M. Stewart

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引用次数: 0

Abstract

Background

The forced oscillation technique (FOT) enables non-invasive measurement of respiratory system impedance. Limited data exists on how changes in operating lung volume (OLV) impact FOT-derived measures of airway resistance (Rrs) and reactance (Xrs).

Objectives

This study examined the reproducibility and responsiveness of FOT-derived measures of Rrs and Xrs during simulated changes in OLV.

Methods

Participants simulated breathing at six OLVs: total lung capacity (TLC), ∼50% of inspiratory reserve volume (IRV₅₀), ∼two-times tidal volume (VT₂), tidal volume (VT), ∼50% of expiratory reserve volume (ERV₅₀), and residual volume (RV), on a commercially available FOT device. Each simulated OLV manuever was performed in triplicate and in random order. Total Rrs and Xrs were recorded at 5, 11, and 19 Hz.

Results

Twelve healthy participants (2 female) completed the study (weight: 76.5 ± 13.6 kg, height: 178.6 ± 9.7 cm, body mass index: 23.9 ± 3.1 kg/m²). Reproducibility of Rrs and Xrs at VT, VT₂ and IRV₅₀ was good to excellent (Range: ICC: 0.89–0.98, 95% confidence interval (CI): 0.70–0.98), while reproducibility at TLC, RV, and ERV₅₀ was poor to excellent (Range: ICC: 0.60–0.98, 95% CI: 0.36–0.97). Rrs and Xrs were not different between VT and VT₂ at any frequency (P > .05). With lung hyperinflation from VT to TLC, Rrs and Xrs decreased at all three frequencies (e.g., At 5 Hz Rrs: mean difference (MD): − 0.89, 95%CI: − 0.03 to − 1.75, P = .04; Xrs: MD: − 0.56, 95%CI: − 0.25 to − 0.86, P < .01). With lung hypoinflated from VT to RV, Rrs increased, and Xrs decreased for all frequencies (e.g., MD at 5 Hz, Rrs: MD: 2.31, 95%CI: 0.94–3.67, P < .01; Xrs: MD: −2.53, 95%CI: −4.02 to −1.04, P < .01).

Conclusion

FOT-derived measures of airway Rrs and Xrs are reproducible across a range of OLV’s, and are responsive to hyper- and hypo-inflation of the lung. To further understand the impact of lung hyper- and hypo-inflation on FOT-derived airway impedance additional study is required in individuals with pathological variations in operating lung volume.

查看原文本刊更多论文

强迫振荡技术在不同肺容量下气道阻抗测量的再现性和反应性。

背景:强迫振荡技术(FOT)使呼吸系统阻抗的无创测量成为可能。关于操作肺体积(OLV)的变化如何影响fft衍生的气道阻力(Rrs)和电抗(Xrs)测量的数据有限。目的:本研究考察了模拟OLV变化过程中fft衍生的Rrs和Xrs测量的可重复性和响应性。方法:参与者在市售的FOT设备上模拟6种olv的呼吸:总肺活量(TLC)、~50%吸气储备量(IRV50)、~ 2倍潮气量(VT2)、潮气量(VT)、~50%呼气储备量(ERV50)和残留量(RV)。每个模拟的OLV操纵都是随机进行的，重复三次。记录5、11和19Hz的总Rrs和Xrs。结果:12名健康受试者(2名女性)完成研究(体重:76.5±13.6kg，身高:178.6±9.7cm，体质指数:23.9±3.1kg/m2)。VT、VT2和IRV50的Rrs和Xrs的再现性从好到优(范围:ICC: 0.89 ~ 0.98, 95%可信区间(CI): 0.70 ~ 0.98)，而TLC、RV和ERV50的再现性从差到优(范围:ICC: 0.60 ~ 0.98, 95% CI: 0.36 ~ 0.97)。VT和VT2在任何频率下的Rrs和Xrs均无差异(P> 0.05)。从VT到TLC的肺恶性膨胀，Rrs和Xrs在所有三个频率上都下降(例如，在5Hz时，Rrs:平均差(MD): -0.89, 95%CI: -0.03至-1.75,P= 0.04;Xrs: MD: -0.56, 95%CI: -0.25至-0.86,p结论:fft衍生的气道Rrs和Xrs测量在OLV范围内是可重复的，并且对肺的高和低充气有反应。为了进一步了解肺高和低充气对fft衍生的气道阻抗的影响，需要对手术肺容量有病理变化的个体进行额外的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.