Morbid obesity influences the nocturnal electrocardiogram wave and interval durations among suspected sleep apnea patients

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2023-11-30 DOI:10.1111/anec.13101

Samu Kainulainen PhD, Aaron Suni BM, Jukka A. Lipponen PhD, Antti Kulkas PhD, Brett Duce BSc, Henri Korkalainen PhD, Sami Nikkonen PhD, Saara Sillanmäki MD, PhD

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Abstract

Background

Obesity is a global issue with a major impact on cardiovascular health. This study explores how obesity influences nocturnal cardiac electrophysiology in suspected obstructive sleep apnea (OSA) patients.

Methods

We randomly selected 12 patients from each of the five World Health Organization body mass index (BMI) classifications groups (n_total = 60) while keeping the group's age and sex matched. We evaluated 1965 nocturnal electrocardiography (ECG) samples (10 s) using modified lead II recorded during normal saturation conditions. R-wave peaks were detected and confirmed using dedicated software, with the exclusion of ventricular extrasystoles and artifacts. The duration of waves and intervals was manually marked. The average electric potential graphs were computed for each segment. Thresholds for abnormal ECG waveforms were P-wave > 120 ms, PQ interval > 200 ms, QRS complex > 120 ms for, and QTc > 440 ms.

Results

Obesity was significantly (p < .05) associated with prolonged conduction times. Compared to the normal weight (18.5 ≤ BMI < 25) group, the morbidly obese patients (BMI ≥ 40) had a significantly longer P-wave duration (101.7 vs. 117.2 ms), PQ interval (175.8 vs. 198.0 ms), QRS interval (89.9 vs. 97.7 ms), and QTc interval (402.8 vs. 421.2 ms). We further examined ECG waveform prolongations related to BMI. Compared to other patient groups, the morbidly obese patients had the highest number of ECG segments with PQ interval (44% of the ECG samples), QRS duration (14%), and QTc duration (20%) above the normal limits.

Conclusions

Morbid obesity predisposes patients to prolongation of cardiac conduction times. This might increase the risk of arrhythmias, stroke, and even sudden cardiac death.

Abstract Image

查看原文本刊更多论文

病态肥胖影响疑似睡眠呼吸暂停患者的夜间心电图波和间隔时间。

背景:肥胖是一个全球性问题，对心血管健康有重大影响。本研究探讨肥胖如何影响疑似阻塞性睡眠呼吸暂停(OSA)患者夜间心脏电生理。方法:在保持年龄和性别匹配的情况下，从世界卫生组织体重指数(BMI)的5个分类组中随机选择12例患者(ntotal = 60)。我们评估了1965例夜间心电图(ECG)样本(10 s)，使用在正常饱和条件下记录的改良II型铅。使用专用软件检测并确认r波峰值，排除室性心动过速和伪影。波浪和间隔的持续时间是手动标记的。计算每段的平均电位图。异常心电图波形阈值为p波> 120 ms、PQ间隔> 200 ms、QRS复合体> 120 ms、QTc > 440 ms。结论:病态肥胖易导致心脏传导时间延长。这可能会增加心律失常、中风甚至心源性猝死的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.