The performance and applied value of ¹⁸F-FDG PET/CT imaging in Waldenstrom macroglobulinemia.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

American journal of nuclear medicine and molecular imaging Pub Date : 2023-10-20 eCollection Date: 2023-01-01

Bo Pan, Xingxing Zhu, Qiang Xie

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引用次数: 0

Abstract

Waldenstrom macroglobulinemia (WM) is a rare inert B lymphocyte lymphoma and the role of FDG PET/CT imaging in WM has not been well established. This study aimed to evaluate the metabolic status of WM by ¹⁸F-FDG PET/CT imaging. We retrospectively analyzed 20 patients who underwent pretherapy ¹⁸F-FDG PET-CT scan. All patients were diagnosed by bone marrow aspiration, laboratory examination and clinical symptoms. Bone marrow involvement was identified with ¹⁸F-FDG PET/CT imaging in 16 of 20, and the mean SUVmax of bone marrow was 4.06±0.85, Lymph nodes were involved in 8 of 20 patients, and the mean SUVmax of Lymph nodes was 4.07±1.27. Liver and spleen were involved in one case respectively, with SUVmax being 3.6 and 3.3. 1 case of extramedullary infiltration and 1 case of lymphomatous transformation. ¹⁸F-FDG PET/CT imaging not only could reveal the metabolic status of lymph nodes, liver, spleen and bone marrow in WM patients, but also evaluate the status of tumor burden which helps to formulate personalized treatment plans.

本刊更多论文

18F-FDG PET/CT在Waldenstrom巨球蛋白血症中的表现及应用价值。

Waldenstrom巨球蛋白血症(WM)是一种罕见的惰性B淋巴细胞淋巴瘤，FDG PET/CT成像在WM中的作用尚未得到很好的确定。本研究旨在通过18F-FDG PET/CT成像评估WM的代谢状态。我们回顾性分析了20例接受治疗前18F-FDG PET-CT扫描的患者。所有患者均通过骨髓穿刺、实验室检查和临床症状确诊。20例患者中有16例经18F-FDG PET/CT检查发现骨髓受累，骨髓平均SUVmax为4.06±0.85,8例患者受累淋巴结，平均SUVmax为4.07±1.27。累及肝脏和脾脏各1例，SUVmax分别为3.6和3.3。髓外浸润1例，淋巴瘤转化1例。18F-FDG PET/CT成像不仅可以显示WM患者的淋巴结、肝脏、脾脏和骨髓的代谢状况，还可以评估肿瘤负荷状况，有助于制定个性化的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.