Lipid Lowering Drugs in Acute Coronary Syndromes (ACS).

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2023-12-01 Epub Date: 2023-11-28 DOI:10.1007/s11883-023-01163-6

Natalie Arnold, Wolfgang Koenig

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Abstract

Purpose of review: The purpose of this review is to critically discuss whether more aggressive lipid-lowering strategies are needed in patients with acute coronary syndromes (ACS).

Recent findings: Currently, available data on early (in-hospital/discharge) administration of potent lipid-lowering drugs, such as proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors in patients during the vulnerable post-ACS phase, have clearly demonstrated clinical efficacy of the "strike early and strike strong" approach not only for rapid reduction of low-density lipoprotein cholesterol (LDL-C) to unprecedentedly low levels, but also for associated favorable composition of coronary plaque. Intensive lipid-lowering therapy with rapid achievement of the LDL-C treatment goal in ACS patients seems reasonable. However, whether such profound LDL-C reduction would result in additional benefit on the reduction of future CV events still has to be established. Thus, data addressing CV outcomes in such vulnerable patients at extreme CV risk are urgently needed.

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急性冠脉综合征(ACS)的降脂药物。

综述的目的:本综述的目的是批判性地讨论急性冠脉综合征(ACS)患者是否需要更积极的降脂策略。最近的调查结果:目前，关于急性冠脉综合征后易感期患者早期(住院/出院)使用强效降脂药物(如proprotein convertase subtilisin/kexin 9 (PCSK9)抑制剂)的现有数据，已经清楚地证明了“早打强打”方法的临床疗效，不仅可以将低密度脂蛋白胆固醇(LDL-C)快速降低到前所未有的低水平，而且还可以使冠脉斑块形成有利的成分。强化降脂治疗快速达到ACS患者LDL-C治疗目标似乎是合理的。然而，这种深度的LDL-C降低是否会对未来心血管事件的减少产生额外的益处仍有待确定。因此，迫切需要针对这些高危患者CV结局的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.