A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2023-11-27 DOI:10.1007/s13659-023-00418-8

Jin-Ning Chu, Premanand Krishnan, Kuan-Hon Lim

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Abstract

Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae family. Indigenous to tropical and subtropical regions of East Asia and India, this species is extensively distributed across China, particularly in the southern regions (Sichuan, Yunnan, and Jiangxi). In addition to its high ornamental value, S. glabra has a rich history of use in traditional Chinese medicine, evident through its empirical prescriptions for various ailments like pneumonia, dysentery, fractures, bruises, numbness, amenorrhea, rheumatism, and other diseases. Besides, modern pharmacological studies have revealed various biological activities, such as antitumour, anti-bacterial, anti-viral anti-inflammatory and immunomodulatory effects. The diverse chemical constituents of S. glabra have fascinated natural product researchers since the 1900s. To date, over 400 compounds including terpenoids, coumarins, lignans, flavonoids, sterols, anthraquinones, organic acids, and organic esters have been isolated and characterised, some featuring unprecedented structures. This review comprehensively examines the current understanding of S. glabra’s phytochemistry and pharmacology, with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker, the lindenane-type sesquiterpenoids.

Graphical Abstract

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本文综述了柴烛属植物的化学成分、倍半萜类生物合成及生物活性研究进展。

(拇指)Nakai是一种多年生常绿草本植物，属于绿兰花科下的Sarcandra Gardner属。本种原产于东亚和印度的热带和亚热带地区，广泛分布于中国，特别是在南部地区(四川，云南和江西)。除了具有很高的观赏价值外，天竺葵在传统中医中有着丰富的使用历史，通过其对各种疾病的经验处方，如肺炎，痢疾，骨折，瘀伤，麻木，闭经，风湿病和其他疾病。此外，现代药理学研究揭示了其多种生物活性，如抗肿瘤、抗菌、抗病毒、抗炎和免疫调节作用。自20世纪以来，天竺葵的多种化学成分一直吸引着天然产品研究人员。迄今为止，已经分离和鉴定了400多种化合物，包括萜类、香豆素、木脂素、黄酮类、甾醇、蒽醌、有机酸和有机酯，其中一些化合物具有前所未有的结构。本文综述了近年来对香桐的植物化学和药理学的研究，重点介绍了香桐独特的化学分类标记——香桐烯型倍半萜类化合物的化学和生物合成。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.