Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica^® IM Solution Immunoassay Analyzer.

IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY

Annals of Clinical Biochemistry Pub Date : 2024-07-01 Epub Date: 2023-12-07 DOI:10.1177/00045632231219387

Marina Giralt, Noelia Díaz-Troyano, Immaculada Comas, Albert Blanco, Laura Conesa, Manel Mendoza, Carles Zafon, María Goya, Roser Ferrer

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Abstract

Background: Gestational hypothyroidism has been shown to be associated with adverse pregnancy outcomes as well as adverse outcomes for the child. Thyroid hormones concentrations change in gestation, especially within the first trimester, so the results of thyroid function test often are outside non-pregnant reference ranges. The objective of this study was to establish the first trimester reference ranges for thyroid stimulating hormone (TSH) and free thyroxine (FT4) for pregnant women in Barcelona (Spain).

Methods: It was a prospective study in which 673 women were recruited during their first trimester of gestation (8-13 weeks). Serum TSH, FT4 and antithyroid peroxidase antibodies (TPOAb) were measured with Atellica^® IM 1600 (Siemens Healthineers). After excluding 418 women, the reference ranges for TSH and FT4 were calculated by the 2.5th and 97.5th percentiles. Potential variables examined in this study were age, body mass index (BMI), ethnicity, iodine supplementation and smoking habit.

Results: The reference ranges established on the Atellica^® IM 1600 for the first trimester pregnancy in our population were 0.111 to 4.291 mIU/L for TSH and 11.45 to 17.76 pmol/L for FT4. No significant differences were found in thyroid hormones concentrations regarding maternal age (≤30 years vs >30 years) (p = .117), iodine supplementation (p = .683) and smoking habit (p = .363). The prevalence of TPOAb was estimated at 10.0%.

Conclusions: We found that in our local population, the optimal TSH upper reference limit in the first trimester of gestation was 4.3 mIU/L, similar to that proposed by de ATA-2017 guideline (4.0 mIU/L).

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使用Atellica®IM溶液免疫分析分析仪检测加泰罗尼亚妇女妊娠早期甲状腺激素的参考范围。

背景:妊娠期甲状腺功能减退已被证明与不良妊娠结局以及儿童不良结局相关。甲状腺激素浓度在妊娠期发生变化，特别是在妊娠早期，因此甲状腺功能检查结果经常超出非妊娠参考范围。本研究的目的是为巴塞罗那(西班牙)的孕妇建立孕早期促甲状腺激素(TSH)和游离甲状腺素(FT4)的参考范围。方法:这是一项前瞻性研究，招募了673名怀孕前三个月(8-13周)的妇女。采用Atellica®im1600 (Siemens Healthineers)检测血清TSH、FT4和抗甲状腺过氧化物酶抗体(TPOAb)。在排除418名女性后，TSH和FT4的参考范围按2.5和97.5%计算。这项研究的潜在变量包括年龄、身体质量指数(BMI)、种族、碘补充剂和吸烟习惯。结果:在Atellica®im1600上建立的早期妊娠人群TSH参考范围为0.111 ~ 4.291 mIU/L, FT4参考范围为11.45 ~ 17.76 pmol/L。母亲年龄(≤30岁vs >30岁)(p=0.117)、碘补充(p=0.683)和吸烟习惯(p=0.363)对甲状腺激素浓度无显著影响。TPOAb的患病率估计为10.0%。结论:我们发现，在我国当地人群中，妊娠前三个月最佳TSH参考上限为4.3 mIU/L，与de ATA-2017指南(4.0 mIU/L)的建议相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).