Role of surface glycans in enveloped RNA virus infections: A structural perspective.

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Proteins-Structure Function and Bioinformatics Pub Date : 2025-01-01 Epub Date: 2023-11-22 DOI:10.1002/prot.26636

Bhawna Pandey, Srividhya S, Ananya Chatterjee, Vidya Mangala Prasad

引用次数: 0

Abstract

Enveloped RNA viruses have been causative agents of major pandemic outbreaks in the recent past. Glycans present on these virus surface proteins are critical for multiple processes during the viral infection cycle. Presence of glycans serves as a key determinant of immunogenicity, but intrinsic heterogeneity, dynamics, and evolutionary shifting of glycans in heavily glycosylated enveloped viruses confounds typical structure-function analysis. Glycosylation sites are also conserved across different viral families, which further emphasizes their functional significance. In this review, we summarize findings regarding structure-function correlation of glycans on enveloped RNA virus proteins.

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表面聚糖在包膜RNA病毒感染中的作用:结构视角。

包膜RNA病毒是近年来主要大流行暴发的病原体。存在于这些病毒表面蛋白上的聚糖对病毒感染周期中的多个过程至关重要。聚糖的存在是免疫原性的关键决定因素，但在糖基化严重的包膜病毒中，聚糖的内在异质性、动力学和进化转移使典型的结构-功能分析变得混乱。糖基化位点在不同的病毒家族中也是保守的，这进一步强调了它们的功能意义。在这篇综述中，我们总结了聚糖在包膜RNA病毒蛋白上的结构-功能相关性的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proteins-Structure Function and Bioinformatics 生物-生化与分子生物学

CiteScore

5.90

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： PROTEINS : Structure, Function, and Bioinformatics publishes original reports of significant experimental and analytic research in all areas of protein research: structure, function, computation, genetics, and design. The journal encourages reports that present new experimental or computational approaches for interpreting and understanding data from biophysical chemistry, structural studies of proteins and macromolecular assemblies, alterations of protein structure and function engineered through techniques of molecular biology and genetics, functional analyses under physiologic conditions, as well as the interactions of proteins with receptors, nucleic acids, or other specific ligands or substrates. Research in protein and peptide biochemistry directed toward synthesizing or characterizing molecules that simulate aspects of the activity of proteins, or that act as inhibitors of protein function, is also within the scope of PROTEINS. In addition to full-length reports, short communications (usually not more than 4 printed pages) and prediction reports are welcome. Reviews are typically by invitation; authors are encouraged to submit proposed topics for consideration.