The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye

IF 2.2 4区医学 Q3 ENGINEERING, BIOMEDICAL

International Journal for Numerical Methods in Biomedical Engineering Pub Date : 2023-11-22 DOI:10.1002/cnm.3791

Lorenzo Sala, Christophe Prud'homme, Giovanna Guidoboni, Marcela Szopos, Alon Harris

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Abstract

We present our continuous efforts from a modeling and numerical viewpoint to develop a powerful and flexible mathematical and computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims to solve problems arising in biomechanics and hemodynamics within the human eye. We discuss our contribution towards improving the reliability and reproducibility of computational studies by performing a thorough validation of the numerical predictions against experimental data. The OMVS proved capable of simulating complex multiphysics and multiscale scenarios motivated by the study of glaucoma. Furthermore, its modular design allows the continuous integration of new models and methods as the research moves forward, and supports the utilization of the OMVS as a promising non-invasive clinical investigation tool for personalized research in ophthalmology.

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眼数学虚拟模拟器:人眼血流动力学和生物力学的验证多尺度模型。

我们从建模和数值的角度提出了我们的持续努力，以开发一个强大而灵活的数学和计算框架，称为眼数学虚拟模拟器(OMVS)。OMVS旨在解决人眼生物力学和血流动力学中出现的问题。我们通过对实验数据的数值预测进行彻底验证，讨论了我们对提高计算研究的可靠性和可重复性的贡献。事实证明，由青光眼研究驱动的OMVS能够模拟复杂的多物理场和多尺度场景。此外，其模块化设计允许随着研究的进展不断集成新的模型和方法，并支持将OMVS作为一种有前途的非侵入性临床研究工具用于眼科个性化研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal for Numerical Methods in Biomedical Engineering ENGINEERING, BIOMEDICAL-MATHEMATICAL & COMPUTATIONAL BIOLOGY

CiteScore

4.50

自引率

9.50%

发文量

103

审稿时长

3 months

期刊介绍： All differential equation based models for biomedical applications and their novel solutions (using either established numerical methods such as finite difference, finite element and finite volume methods or new numerical methods) are within the scope of this journal. Manuscripts with experimental and analytical themes are also welcome if a component of the paper deals with numerical methods. Special cases that may not involve differential equations such as image processing, meshing and artificial intelligence are within the scope. Any research that is broadly linked to the wellbeing of the human body, either directly or indirectly, is also within the scope of this journal.