Development and Challenges of Cyclic Peptides for Immunomodulation.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2024-01-01 DOI:10.2174/0113892037272528231030074158

Xianqiong Jiang, Li Gao, Zhilong Li, Yan Shen, Zhi-Hua Lin

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引用次数: 0

Abstract

Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammatory, anti-virus, treatment of multiple sclerosis and membranous nephropathy through immunomodulation. In order to know more useful information about cyclic peptides in clinical research and drug application, this paper also summarizes cyclic peptides currently in the clinical trial stage and cyclic peptide drugs approved for marketing in the recent five years. Cyclic peptides have many advantages and great potential in treating various diseases, but there are still many challenges to be solved in the development process of cyclic peptides.

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免疫调节环肽的发展和挑战。

环肽是由蛋白质衍生或非蛋白质衍生氨基酸之间的酰胺键的环状序列形成的多肽链。与线性肽相比，环肽具有稳定性高、亲和力强、选择性强、毒性低等优点。环肽已被证明在医学领域具有广阔的应用前景。此外，本文主要阐述了环肽在抗癌、抗炎、抗病毒、通过免疫调节治疗多发性硬化症和膜性肾病等方面的重要作用。为了了解更多关于环肽在临床研究和药物应用中的有用信息，本文还对目前处于临床试验阶段的环肽和近五年来获准上市的环肽药物进行了综述。环肽在治疗多种疾病方面具有许多优势和巨大潜力，但在环肽的开发过程中仍有许多挑战需要解决。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.