From bench to bedside: potential of translational research in COVID-19 and beyond.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Briefings in Functional Genomics Pub Date : 2024-07-19 DOI:10.1093/bfgp/elad051

Nityendra Shukla, Uzma Shamim, Preeti Agarwal, Rajesh Pandey, Jitendra Narayan

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引用次数: 0

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) have been around for more than 3 years now. However, due to constant viral evolution, novel variants are emerging, leaving old treatment protocols redundant. As treatment options dwindle, infection rates continue to rise and seasonal infection surges become progressively common across the world, rapid solutions are required. With genomic and proteomic methods generating enormous amounts of data to expand our understanding of SARS-CoV-2 biology, there is an urgent requirement for the development of novel therapeutic methods that can allow translational research to flourish. In this review, we highlight the current state of COVID-19 in the world and the effects of post-infection sequelae. We present the contribution of translational research in COVID-19, with various current and novel therapeutic approaches, including antivirals, monoclonal antibodies and vaccines, as well as alternate treatment methods such as immunomodulators, currently being studied and reiterate the importance of translational research in the development of various strategies to contain COVID-19.

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从实验室到床边:2019冠状病毒病及其他领域转化研究的潜力

严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)和冠状病毒病2019 (COVID-19)已经存在3年多了。然而，由于病毒不断进化，新的变异不断出现，使旧的治疗方案变得多余。随着治疗选择减少，感染率继续上升，季节性感染激增在世界各地日益普遍，需要快速解决办法。随着基因组学和蛋白质组学方法产生了大量数据，以扩大我们对SARS-CoV-2生物学的理解，迫切需要开发新的治疗方法，使转化研究得以蓬勃发展。在这篇综述中，我们重点介绍了COVID-19在世界上的现状以及感染后后遗症的影响。我们介绍了COVID-19转化研究的贡献，包括目前正在研究的各种现有和新型治疗方法，包括抗病毒药物、单克隆抗体和疫苗，以及免疫调节剂等替代治疗方法，并重申了转化研究在制定各种遏制COVID-19策略中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Briefings in Functional Genomics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY

CiteScore

6.30

自引率

2.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data. The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.