The Wave Model of Sleep Dynamics and an Invariant Relationship between NonREM and REM Sleep.

IF 2.1 Q3 CLINICAL NEUROLOGY
Vasili Kharchenko, Irina V Zhdanova
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引用次数: 0

Abstract

Explaining the complex structure and dynamics of sleep, which consist of alternating and physiologically distinct nonREM and REM sleep episodes, has posed a significant challenge. In this study, we demonstrate that a single-wave model concept captures the distinctly different overnight dynamics of the four primary sleep measures-the duration and intensity of nonREM and REM sleep episodes-with high quantitative precision for both regular and extended sleep. The model also accurately predicts how these polysomnographic measures respond to sleep deprivation or abundance. Furthermore, the model passes the ultimate test, as its prediction leads to a novel experimental finding-an invariant relationship between the duration of nonREM episodes and the intensity of REM episodes, the product of which remains constant over consecutive sleep cycles. These results suggest a functional unity between nonREM and REM sleep, establishing a comprehensive and quantitative framework for understanding normal sleep and sleep disorders.

睡眠动力学的波模型及非快速眼动和快速眼动睡眠的不变关系。
解释睡眠的复杂结构和动力学,包括交替和生理上不同的非快速眼动和快速眼动睡眠,已经提出了重大挑战。在这项研究中,我们证明了单波模型概念捕捉了四种主要睡眠测量的明显不同的夜间动态——非快速眼动睡眠和快速眼动睡眠的持续时间和强度——对常规睡眠和延长睡眠都有很高的定量精度。该模型还准确地预测了这些多导睡眠图测量对睡眠剥夺或充足的反应。此外,该模型通过了最终测试,因为它的预测导致了一个新的实验发现——非快速眼动发作的持续时间和快速眼动发作的强度之间存在不变的关系,其结果在连续的睡眠周期中保持不变。这些结果表明非快速眼动睡眠和快速眼动睡眠在功能上是统一的,为理解正常睡眠和睡眠障碍建立了全面和定量的框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
7 weeks
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