Use of Fosaprepitant for Management of Suspected Antimicrobial-Associated Nausea: A Case Report.

IF 0.9 Q3 ANESTHESIOLOGY
Brandon Perkovich, Rabia S Atayee, Jennifer S Kim, Tamara Rubenzik
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引用次数: 0

Abstract

Intractable nausea can occur in numerous settings. We report on a 49-year-old woman with a past medical history of cystic fibrosis (CF) with chronic hypoxia, chronic nausea, complex infection history and frequent hospitalizations who was admitted to an academic medical center with a CF exacerbation. Her chronic nausea worsened with the use of antimicrobials, and she was unable to tolerate dopamine or serotonin antagonist antiemetics. Nausea persisted despite the use of benzodiazepines and antihistamines. She was given a one-time dose of fosaprepitant 150 mg intravenously (IV) with marked improvement of her nausea. During subsequent exacerbations, she again developed severe nausea which continued to respond well to a one-time dose of fosaprepitant 150 mg IV. Fosaprepitant is a substance P/neurokinin-1 (NK1) receptor antagonist that is FDA-approved for the prevention of chemotherapy-induced nausea and vomiting and has been used to prevent post-operative nausea and vomiting. Its use in other contexts has not been well established. This case suggests a role for fosaprepitant in the management of nausea outside the context of chemotherapy or general anesthesia.

使用磷沙匹坦治疗疑似抗菌素相关恶心:1例报告。
难治性恶心可发生在许多情况下。我们报告一名49岁女性,既往有囊性纤维化(CF)病史,伴慢性缺氧、慢性恶心、复杂感染史和频繁住院,因CF加重入住学术医疗中心。她的慢性恶心随着抗菌素的使用而恶化,并且她无法耐受多巴胺或血清素拮抗剂止吐药。尽管使用苯二氮卓类药物和抗组胺药,恶心仍然存在。患者一次性静脉滴注氟沙匹坦150毫克,恶心症状明显改善。在随后的加重中,患者再次出现严重的恶心,对一次性剂量的fosaprepitant 150mg IV持续反应良好。fosaprepitant是一种物质P/神经动素-1 (NK1)受体拮抗剂,fda批准用于预防化疗引起的恶心和呕吐,并已用于预防术后恶心和呕吐。它在其他语境中的用法尚未得到很好的确定。本病例提示氟沙吡坦在化疗或全身麻醉以外的恶心治疗中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
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