[Pancreatoduodenal transplantation with and without the spleen in an animal experiment].

P Friess, H Lippert
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Abstract

It is a report on the heterotop transplantation of the pancreas with duodenum with or without spleen to diabetic mini-pigs. 7 days after a total resection of the pancreas the truncus coeliacus of the transplant is anastomosed end-to-side with the distal aorta. The same is done with the vena cava inferior. After having closed the duodenum orally the pancreatic juice is drained through on anus praeter. The immunosuppression is reached by giving Cyclosporin A and prednisolone after having analyzed the blood picture. The postoperative laboratory tests as well as affection tests including selective angiographic and nuclear medical in vivo controls show the efficiency of this transplantation variant to control a diabetic metabolic level for several weeks without an external insulin supply. The transplantation model described is technically uncomplicated and it is the basis for further studies.

[带脾和不带脾的胰十二指肠移植动物实验]。
本文报道了带脾或不带脾的胰腺十二指肠异体顶移植术。胰腺全切除7天后,移植腹腔干端侧与远端主动脉吻合。下腔静脉也是如此。经口关闭十二指肠后,胰液通过肛门排出。分析血象后给予环孢素A和强的松龙免疫抑制。术后实验室测试以及包括选择性血管造影和核医学体内对照在内的影响测试表明,这种移植变体在没有外部胰岛素供应的情况下可以有效地控制糖尿病代谢水平数周。所描述的移植模型在技术上并不复杂,是进一步研究的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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