Toxoplasma gondii infection of the central nervous system and suicide: A case-control study of decedents.

European journal of microbiology & immunology Pub Date : 2023-11-20 Print Date: 2023-11-23 DOI:10.1556/1886.2023.00033

Laura Alejandra Mendoza-Larios, Fernando García-Dolores, Luis Francisco Sánchez-Anguiano, Elizabeth Irasema Antuna-Salcido, Jesús Hernández-Tinoco, Adriana Rocha-Salais, Marcela Araceli Segoviano-Mendoza, Antonio Sifuentes-Álvarez, Cosme Alvarado-Esquivel

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Abstract

We sought to determine the association between Toxoplasma gondii (T. gondii) infection of the central nervous system and suicide in a sample of decedents in Mexico City. One hundred and forty-seven decedents (87 who committed suicide and 60 who did not commit suicide) were studied. Brain tissues (amygdala and prefrontal cortex) of decedents were examined for the detection of T. gondii using immunohistochemistry. Detection of T. gondii was positive in 7 (8.0%) of the 87 cases (6 found in prefrontal cortex and one in amygdala), and in one (1.7%) of the 60 controls (found in prefrontal cortex) (OR: 5.16; 95% CI: 0.61-43.10; P = 0.14). Results suggest that T. gondii infection in brain is not associated with suicide. Further studies to confirm this finding are needed.

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刚地弓形虫感染中枢神经系统与自杀:死者病例对照研究。

我们试图在墨西哥城的一个死者样本中确定刚地弓形虫(弓形虫)感染中枢神经系统与自杀之间的关系。147名死者(87名自杀者和60名未自杀者)被研究。采用免疫组化方法检测死者脑组织(杏仁核和前额叶皮层)的弓形虫。87例患者中有7例(8.0%)检测出弓形虫阳性(6例在前额叶皮层，1例在杏仁核)，60例对照中有1例(1.7%)检测出弓形虫阳性(OR: 5.16;95% ci: 0.61-43.10;P = 0.14)。结果提示，脑内弓形虫感染与自杀无关。需要进一步的研究来证实这一发现。

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European journal of microbiology & immunology

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