The impact of genetic polymorphisms on genotoxicity in workers occupationally exposed to pesticides: a systematic review.

IF 3.2 4区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Toxicology Mechanisms and Methods Pub Date : 2024-03-01 Epub Date: 2023-11-20 DOI:10.1080/15376516.2023.2280806

Thiago Guedes Pinto, Glenda Nicioli da Silva, Ana Claudia Muniz Renno, Daisy Maria Favero Salvadori, Daniel Araki Ribeiro

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Abstract

In a world with a rising use of pesticides, these chemicals, although designed to effectively control pests, pose potential threats to the environment and non-target organisms, including humans. Thus, this systematic review aims to investigate a possible association between genetic polymorphisms and susceptibility and genotoxicity in individuals occupationally exposed to pesticides. This review was conducted following the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. A total of 14 carefully selected studies were thoroughly analyzed by two reviewers, who assigned scores based on previously set evaluation criteria. This study classified over half of the chosen studies as having moderate or strong quality, observing a correlation between certain genetic polymorphisms involved in xenobiotic metabolism and genotoxicity in workers exposed to pesticides. Results suggest that the genes associated with xenobiotic metabolism play a substantial role in determining individuals' susceptibility to genomic damage due to pesticide exposure, affecting both their peripheral blood and oral mucosa. This implies that individuals with specific genotypes may experience increased or decreased levels of DNA damage when exposed to these chemicals.

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遗传多态性对职业农药暴露工人遗传毒性的影响:系统综述。

在一个农药使用量不断增加的世界，这些化学品虽然旨在有效控制害虫，但对环境和包括人类在内的非目标生物构成潜在威胁。因此，本系统综述旨在探讨职业农药暴露个体的遗传多态性与易感性和遗传毒性之间的可能关联。本综述按照2020年系统评价和荟萃分析(PRISMA)标准的首选报告项目进行。共有14项精心挑选的研究由两名审稿人进行了彻底的分析，他们根据先前设定的评估标准进行评分。这项研究将一半以上的研究归类为中等或高质量的研究，观察到接触农药工人中涉及外源代谢的某些遗传多态性与遗传毒性之间的相关性。结果表明，与外源代谢相关的基因在决定个体对农药暴露导致的基因组损伤的易感性方面起着重要作用，影响其外周血和口腔黏膜。这意味着具有特定基因型的个体在暴露于这些化学物质时可能会经历或多或少的DNA损伤水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology Mechanisms and Methods 医学-毒理学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.