Hormones, oxidized proteins, and lipids in alcoholism. Duration of remission.

IF 1.1 4区医学 Q4 SUBSTANCE ABUSE

Journal of Ethnicity in Substance Abuse Pub Date : 2024-07-01 Epub Date: 2023-11-20 DOI:10.1080/15332640.2023.2280089

Tamara P Vetlugina, Valentina D Prokopieva, Nikolay A Bokhan, Valentina B Nikitina, Olga A Lobacheva, Anna I Mandel

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Abstract

The instability of remission in alcohol dependence (AD) creates a need to search for criteria for predicting its duration. The aim of study was to determine the hormones, oxidized proteins, and lipids in patients with AD, and the possible relations between these parameters and the duration of remission. Blood samples were obtained from 49 male patients with AD after alcohol detoxification (Total group). Two groups of patients were formed: with unstable therapeutic remission up to 6 months (UTR-group); with stable therapeutic remission which lasted 12 months or longer (STR-group). The control group comprised men without AD. The levels of carbonylated proteins (CP), lipid peroxidation (TBA-RS) were determined in the blood plasma. The levels of cortisol, testosterone total, thyroid-stimulating hormone (TSH), triiodothyronine free (fT3), and thyroxine free (fT4) in the blood serum were measured. The Total group of patients showed an increase in CP, TBA-RS, Cortisol, cortisol/testosterone ratio, and a decrease in TSH, fT3, and fT3/fT4 levels. A set of parameters (T, fT3, fT4, cortisol/testosterone ratio) associated with unstable remission was identified.

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酒精中毒中的激素、氧化蛋白和脂质。缓解持续时间。

酒精依赖(AD)缓解的不稳定性需要寻找预测其持续时间的标准。研究的目的是确定AD患者的激素、氧化蛋白和脂质，以及这些参数与缓解时间之间的可能关系。49例男性AD患者酒精解毒后采血(Total组)。患者分为两组:治疗缓解不稳定达6个月(utr组);治疗缓解稳定持续12个月或更长时间(str组)。对照组由没有AD的男性组成。测定血浆中羰基化蛋白(CP)、脂质过氧化(TBA-RS)水平。测定血清皮质醇、总睾酮、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)水平。Total组患者CP、TBA-RS、皮质醇、皮质醇/睾酮比值升高，TSH、fT3和fT3/fT4水平降低。确定了与不稳定缓解相关的一组参数(T、fT3、fT4、皮质醇/睾酮比值)。

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来源期刊

Journal of Ethnicity in Substance Abuse SUBSTANCE ABUSE-

CiteScore

3.20

自引率

7.70%

发文量

期刊介绍： The Journal of Ethnicity in Substance Abuse presents rigorous new studies and research on ethnicity and cultural variation in alcohol, tobacco, licit and illicit forms of substance use and abuse. The research is drawn from many disciplines and interdisciplinary areas in the social and behavioral sciences, public health, and helping professions. The Journal of Ethnicity in Substance Abuse is an international forum for identification of emergent and culturally diverse substance use and abuse trends, and the implementation of culturally competent strategies in harm reduction, individual, group, and family treatment of substance abuse. The Journal systematically investigates the beliefs, attitudes, and values of substance abusers, searching for the answers to the origins of drug use and abuse for different ethnic groups. The Journal publishes research papers, review papers, policy commentaries, and conference proceedings. The Journal welcomes submissions from across the globe, and strives to ensure efficient review and publication outcomes.