Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2023-11-19 DOI:10.1007/s11418-023-01760-4

Richiro Ushimaru

引用次数: 0

Abstract

Epoxides, aziridines, and cyclopropanes are found in various medicinal natural products, including polyketides, terpenes, peptides, and alkaloids. Many classes of biosynthetic enzymes are involved in constructing these ring structures during their biosynthesis. This review summarizes our current knowledge regarding how α-ketoglutarate-dependent nonheme iron enzymes catalyze the formation of epoxides, aziridines, and cyclopropanes in nature, with a focus on enzyme mechanisms.

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α-酮戊二酸依赖性非血红素铁酶催化的三元环形成。

环氧化物、氮嘧啶和环丙烷存在于各种药用天然产物中，包括聚酮、萜烯、多肽和生物碱。在生物合成过程中，许多种类的生物合成酶都参与了这些环结构的构建。本文综述了α-酮戊二酸依赖性非血红素铁酶在自然界中如何催化环氧化物、氮丙啶和环丙烷的形成，并重点讨论了酶的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.