Salivary uric acid sensor using the fordable “Finger-Powered” microfluidic device

IF 0.5 4区工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC

Electronics and Communications in Japan Pub Date : 2022-07-30 DOI:10.1002/ecj.12363

Hiroyuki Kudo, Takuya Shibahara, Yoshiki Tojyo

{"title":"Salivary uric acid sensor using the fordable “Finger-Powered” microfluidic device","authors":"Hiroyuki Kudo, Takuya Shibahara, Yoshiki Tojyo","doi":"10.1002/ecj.12363","DOIUrl":null,"url":null,"abstract":"<p>Here, we report a novel biosensing system using a finger-powered microfluidic device, which is suitable for daily self-testing of uric acid in saliva. To realize the rapid determination of salivary uric acid, the biosensing system measures directly from the paper-based saliva sampling device. The microfluidic device has the diaphragm pump, the reagent reservoir, and the reaction cell in which the electrochemical uric acid biosensor is embedded. Once the microfluidic chip has been folded, the finger-powered microfluidic device prepares the reagent containing the saliva, which is ready to measure. A wireless potentiostat for electrochemical measurement of uric acid with the biosensor was also developed. Combining these elements together, the whole process from saliva sampling to determination was completed in less than a minute (Sensitivity: 0.03 nA/<i>μ</i>M). The measurement results were also consistent with that measured using a commercially available uric acid determination kit. Hence, our method is expected to have the potential to enhance the use of biochemical information in the field of healthcare IoT.</p>","PeriodicalId":50539,"journal":{"name":"Electronics and Communications in Japan","volume":"105 3","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electronics and Communications in Japan","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ecj.12363","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

Here, we report a novel biosensing system using a finger-powered microfluidic device, which is suitable for daily self-testing of uric acid in saliva. To realize the rapid determination of salivary uric acid, the biosensing system measures directly from the paper-based saliva sampling device. The microfluidic device has the diaphragm pump, the reagent reservoir, and the reaction cell in which the electrochemical uric acid biosensor is embedded. Once the microfluidic chip has been folded, the finger-powered microfluidic device prepares the reagent containing the saliva, which is ready to measure. A wireless potentiostat for electrochemical measurement of uric acid with the biosensor was also developed. Combining these elements together, the whole process from saliva sampling to determination was completed in less than a minute (Sensitivity: 0.03 nA/μM). The measurement results were also consistent with that measured using a commercially available uric acid determination kit. Hence, our method is expected to have the potential to enhance the use of biochemical information in the field of healthcare IoT.

查看原文本刊更多论文

唾液尿酸传感器采用可负担的“手指供电”微流体装置

在这里，我们报告了一种新型的生物传感系统，该系统使用手指驱动的微流体装置，适用于唾液中尿酸的日常自测。为了实现唾液尿酸的快速测定，生物传感系统直接从基于纸张的唾液采样装置进行测量。所述微流控装置具有隔膜泵、试剂储液器和嵌入电化学尿酸生物传感器的反应池。一旦微流控芯片被折叠，手指驱动的微流控装置就会准备含有唾液的试剂，准备进行测量。并研制了一种用于尿酸电化学测量的无线恒电位器。将这些元素结合在一起，在不到1分钟的时间内完成从唾液取样到测定的整个过程(灵敏度:0.03 nA/μM)。测量结果也与市售尿酸测定试剂盒的测量结果一致。因此，我们的方法有望增强生物化学信息在医疗物联网领域的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Electronics and Communications in Japan 工程技术-工程：电子与电气

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Electronics and Communications in Japan (ECJ) publishes papers translated from the Transactions of the Institute of Electrical Engineers of Japan 12 times per year as an official journal of the Institute of Electrical Engineers of Japan (IEEJ). ECJ aims to provide world-class researches in highly diverse and sophisticated areas of Electrical and Electronic Engineering as well as in related disciplines with emphasis on electronic circuits, controls and communications. ECJ focuses on the following fields: - Electronic theory and circuits, - Control theory, - Communications, - Cryptography, - Biomedical fields, - Surveillance, - Robotics, - Sensors and actuators, - Micromachines, - Image analysis and signal analysis, - New materials. For works related to the science, technology, and applications of electric power, please refer to the sister journal Electrical Engineering in Japan (EEJ).