[Antifungal activity of itraconazole and ketoconazole investigated in vitro, determined with minimal inhibitory concentrations and mycelial cell transformation in Candida albicans].

IF 0.5 Q4 DERMATOLOGY

Przeglad dermatologiczny Pub Date : 1989-09-01

S Urbanowski, E Nierebińska, Z Gwieździński

引用次数: 0

Abstract

Results of studies "in vitro" of the susceptibility of 82 strains of Candida albicans for itraconazole and ketoconazole have been report. The strains were isolated from lesions of the mucous membranes and skin. The susceptibility of Candida albicans was tested to Minimal Inhibitory Concentration (MIC) and Total Inhibition Germination Tubes (TI100). The values of MICs and TI100 of itraconazole were 0.02-35.0 micrograms/ml and 0.02-18.0 micrograms/ml, respectively. The similar values of MICs and TI100 of ketoconazole were 0.04-80.0 micrograms/ml and 0.04-20.0 micrograms/ml. It has been showed that TI100 can be used as preliminary and rapid test of Candida albicans susceptibility for these drugs.

本刊更多论文

[体外研究了伊曲康唑和酮康唑的抗真菌活性，测定了最低抑菌浓度和白色念珠菌的菌丝细胞转化]。

报道了82株白色念珠菌对伊曲康唑和酮康唑的“体外”药敏试验结果。这些菌株是从粘膜和皮肤病变中分离出来的。采用最小抑制浓度(MIC)和总抑制萌发管(TI100)检测白色念珠菌的敏感性。伊曲康唑的mic值为0.02 ~ 35.0微克/ml, TI100值为0.02 ~ 18.0微克/ml。酮康唑的mic值为0.04 ~ 80.0微克/ml, TI100值为0.04 ~ 20.0微克/ml。结果表明，TI100可作为白色念珠菌对这些药物敏感性的初步快速检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Przeglad dermatologiczny DERMATOLOGY-

CiteScore

0.80

自引率

14.30%

发文量

审稿时长

12 weeks

期刊介绍： Przegląd Dermatologiczny (ang. Dermatological Review) is a bimonthly magazine of the Polish Dermatological Association. It publishes original (clinical and experimental) papers, review papers, care reports, reports from congresses, reviews of books, announcements, letters to the editor and special papers (requested by the editors), concerning selected dermatological and interdisciplinary issues. Papers sent to the editor are reviewed.