The effects of anodal tDCS on pain reduction in people with knee osteoarthritis: A systematic review and meta-analysis

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2023-11-18 DOI:10.1016/j.neucli.2023.102921

Thusharika Dissanayaka , Piumi Nakandala , Kavinda Malwanage , Aron T. Hill , Deborah N. Ashthree , Melissa M. Lane , Nikolaj Travicia , Elizabeth Gamage , Wolfgang Marx , Shapour Jaberzadeh

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引用次数: 1

Abstract

Objectives

To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA).

Methods

The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement.

Results

Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision.

Discussion and Conclusion

A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings.

Significance

A-tDCS can be used as a standalone and adjunct treatment for KOA.

Study registration

PROSPERO number CRD42021255114

查看原文本刊更多论文

负极tDCS对膝关节骨关节炎患者疼痛减轻的影响:一项系统回顾和荟萃分析

目的综合有关原发性运动皮质阳极经颅直流电刺激(M1-a-tDCS)作为单独或启动技术减轻膝关节骨关节炎(KOA)患者疼痛的疗效的文献。方法根据PRISMA声明在MEDLINE、CINAHL、Embase和CENTRAL进行系统文献检索。结果共纳入14项研究，涉及740例KOA患者。在meta分析中，6项研究比较了a-tDCS单独与假手术刺激，5项研究比较了a-tDCS联合其他方法与假手术刺激。我们发现单独使用a-tDCS对KOA患者疼痛有积极影响(标准平均差(SMD) - 0.52;95% CI，−0.78 ~−0.25;P = 0.001;i2 = 69%)。此外，a-tDCS联合其他处理显示出积极的效果(SMD - 1.23;95% CI，−1.59 ~−0.88;术中,0.001;I2 = 48%)对KOA患者疼痛的影响。由于高偏倚和不精确的风险，该证据的确定性较低。讨论与结论a - tdcs可作为KOA患者减轻疼痛的独立治疗和辅助治疗。未来的随机研究应该解决质量问题，包括小样本量，以提高研究结果的总体确定性。意义- tdcs可作为KOA的独立治疗和辅助治疗。研究注册号为CRD42021255114

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.